{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:13:04Z","timestamp":1777936384106,"version":"3.51.4"},"reference-count":50,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2018,2,18]],"date-time":"2018-02-18T00:00:00Z","timestamp":1518912000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vasc Med"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>\n                    Early-phase clinical trials in patients with critical limb ischemia (CLI) have shown positive results of mononuclear cell therapy. The current meta-analysis investigated whether cluster of differentiation (CD) 34\n                    <jats:sup>+<\/jats:sup>\n                    mononuclear cell therapy (CD34\n                    <jats:sup>+<\/jats:sup>\n                    MCT) is effective for no-option CLI. Ten randomized controlled clinical studies of CD34\n                    <jats:sup>+<\/jats:sup>\n                    MCT for no-option CLI with 479 patients were identified and analyzed for pooled results. Compared to control groups, the CD34\n                    <jats:sup>+<\/jats:sup>\n                    MCT was associated with lower total amputation (odds ratio (OR): 0.45, p=0.01; 95% confidence interval (CI): 0.24\u20130.85) and a higher complete ulcer healing rate (OR: 2.80, p=0.008; 95% CI: 1.31\u20136.02), but showed no advantage in major amputation (OR: 0.58, p=0.11; 95% CI: 0.29\u20131.14) and all-cause mortality (OR: 0.82, p=0.62; 95% CI: 0.36\u20131.83) . Studies with a high CD34\n                    <jats:sup>+<\/jats:sup>\n                    cell dosage showed significant results in major amputation (OR: 0.38, p=0.002; 95% CI: 0.21\u20130.70), total amputation (OR: 0.31, p=0.0002; 95% CI: 0.17\u20130.57) and complete ulcer healing (OR: 7.58, p=0.0005; 95% CI: 2.40\u201323.88), which were not observed in the low-dose studies. However, inclusion of placebo-controlled studies showed no improvement of the CD34\n                    <jats:sup>+<\/jats:sup>\n                    MCT in total amputation (OR: 0.67, p=0.42; 95% CI: 0.25\u20131.79), major amputation (OR: 1.31, p=0.43; 95% CI: 0.67\u20132.54) or complete ulcer healing (OR: 1.52, p=0.27; 95% CI: 0.72\u20133.21), which were extremely significant in non-placebo-controlled studies ( p&lt;0.001). In conclusion, the significant results of CD34\n                    <jats:sup>+<\/jats:sup>\n                    MCT might not support its therapeutic benefit due to high placebo-effect risk and considerable heterogeneity caused by distinct cell doses. More sizable double-blinded, randomized, placebo-controlled trials with higher CD34\n                    <jats:sup>+<\/jats:sup>\n                    cell dosage are needed in the future.\n                  <\/jats:p>","DOI":"10.1177\/1358863x17752556","type":"journal-article","created":{"date-parts":[[2018,2,19]],"date-time":"2018-02-19T01:34:55Z","timestamp":1519004095000},"page":"219-231","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Therapeutic efficacy of CD34\n                    <sup>+<\/sup>\n                    cell-involved mononuclear cell therapy for no-option critical limb ischemia: A meta-analysis of randomized controlled clinical trials"],"prefix":"10.1177","volume":"23","author":[{"given":"Tianyue","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Hematology, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3754-2458","authenticated-orcid":false,"given":"Zhihui","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiguo","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,2,18]]},"reference":[{"key":"bibr1-1358863X17752556","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2006.12.037"},{"key":"bibr2-1358863X17752556","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-11-0552"},{"key":"bibr3-1358863X17752556","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-13-0020"},{"key":"bibr4-1358863X17752556","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.5.547"},{"key":"bibr5-1358863X17752556","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2009.12.001"},{"key":"bibr6-1358863X17752556","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.08.033"},{"key":"bibr7-1358863X17752556","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.942383"},{"key":"bibr8-1358863X17752556","doi-asserted-by":"publisher","DOI":"10.14797\/mdcj-9-4-201"},{"key":"bibr9-1358863X17752556","first-page":"D8347","volume":"2014","author":"Moazzami K","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr10-1358863X17752556","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.309045"},{"key":"bibr11-1358863X17752556","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.253286"},{"key":"bibr12-1358863X17752556","doi-asserted-by":"publisher","DOI":"10.1186\/scrt114"},{"key":"bibr13-1358863X17752556","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2012.04.067"},{"key":"bibr14-1358863X17752556","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2005.12.037"},{"key":"bibr15-1358863X17752556","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2013-0005"},{"key":"bibr16-1358863X17752556","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.07.050"},{"key":"bibr17-1358863X17752556","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.110"},{"key":"bibr18-1358863X17752556","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-13-0864"},{"key":"bibr19-1358863X17752556","doi-asserted-by":"publisher","DOI":"10.1002\/stem.207"},{"key":"bibr20-1358863X17752556","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2013.01.037"},{"key":"bibr21-1358863X17752556","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2010.02.007"},{"key":"bibr22-1358863X17752556","first-page":"775","volume":"56","author":"Gulati A","year":"2015","journal-title":"J Cardiovasc Surg (Torino)"},{"key":"bibr23-1358863X17752556","unstructured":"Higgins JPT, Green S (eds). 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