{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T08:14:04Z","timestamp":1793261644070,"version":"4.5.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T00:00:00Z","timestamp":1563926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vasc Med"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>\n                    In patients with symptomatic peripheral artery disease (PAD), the impact of chronic kidney disease (CKD) on major adverse cardiovascular events has not been fully evaluated. The Examining Use of Ticagrelor In PAD (EUCLID) trial randomized 13,885 patients with PAD to ticagrelor 90 mg twice daily or clopidogrel 75 mg daily. This post hoc analysis compared the incidence of the primary composite endpoint (cardiovascular death, myocardial infarction (MI), or ischemic stroke) in patients with CKD (eGFR &lt; 60 mL\/min\/1.73 m\n                    <jats:sup>2<\/jats:sup>\n                    ) with those without CKD (eGFR \u2a7e 60 mL\/min\/1.73 m\n                    <jats:sup>2<\/jats:sup>\n                    ). The primary safety endpoint was thrombolysis in MI (TIMI) major bleeding. A total of 13,483 patients were included; 3332 (25%) had CKD, of whom 237 had stage 4\/5 disease. Median follow-up was approximately 30 months. After statistical adjustment, patients with CKD had a higher rate of the primary endpoint compared with those without CKD (6.75 vs 3.72 events\/100 patient-years; adjusted hazard ratio (HR) 1.45, 95% CI 1.30\u20131.63). CKD was not associated with increased risk of hospitalization for acute limb ischemia (ALI) (adjusted HR 0.96, 95% CI 0.69\u20131.34) or major amputation (adjusted HR 0.92, 95% CI 0.66\u20131.28). CKD was not associated with a significantly increased risk of major bleeding (adjusted HR 1.21, 95% CI 0.89\u20131.64), but minor bleeding was significantly increased (adjusted HR 1.51, 95% CI 1.07\u20132.15). In conclusion, patients with PAD and CKD had higher rates of cardiovascular death, MI, and ischemic stroke, but similar rates of ALI, major amputation, and TIMI major bleeding when compared with patients without CKD. ClinicalTrials.gov Identifier: NCT01732822\n                  <\/jats:p>","DOI":"10.1177\/1358863x19864172","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T11:42:55Z","timestamp":1563968575000},"page":"422-430","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Chronic kidney disease and risk for cardiovascular and limb outcomes in patients with symptomatic peripheral artery disease: The EUCLID trial"],"prefix":"10.1177","volume":"24","author":[{"given":"Charles W","family":"Hopley","sequence":"first","affiliation":[{"name":"Department of Medicine, Section of Nephrology and Hypertension, Geisel School of Medicine at Dartmouth, Dartmouth Hitchcock Medical Center, Hanover, NH, USA"},{"name":"CPC Clinical Research, Aurora, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Kavanagh","sequence":"additional","affiliation":[{"name":"CPC Clinical Research, Aurora, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manesh R","family":"Patel","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Durham, NC, USA"},{"name":"Department of Medicine, Division of Cardiology, Duke University School of Medicine, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cara","family":"Ostrom","sequence":"additional","affiliation":[{"name":"CPC Clinical Research, Aurora, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Baumgartner","sequence":"additional","affiliation":[{"name":"Swiss Cardiovascular Centre, Inselspital, Division of Angiology, Bern University Hospital, University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8216-4647","authenticated-orcid":false,"given":"Jeffrey S","family":"Berger","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Surgery, New York University School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juuso I","family":"Blomster","sequence":"additional","affiliation":[{"name":"Turku University Hospital, University of Turku, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F Gerry R","family":"Fowkes","sequence":"additional","affiliation":[{"name":"Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W Schuyler","family":"Jones","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Durham, NC, USA"},{"name":"Department of Medicine, Division of Cardiology, Duke University School of Medicine, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian G","family":"Katona","sequence":"additional","affiliation":[{"name":"AstraZeneca Gaithersburg, Gaithersburg, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth W","family":"Mahaffey","sequence":"additional","affiliation":[{"name":"Stanford Center for Clinical Research, Stanford University School of Medicine, Stanford, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Norgren","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, \u00d6rebro University, \u00d6rebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank W","family":"Rockhold","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7571-7557","authenticated-orcid":false,"given":"William R","family":"Hiatt","sequence":"additional","affiliation":[{"name":"CPC Clinical Research, Aurora, CO, USA"},{"name":"Department of Medicine, Division of Cardiology, University of Colorado School of Medicine, Aurora, CO, 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