{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T10:40:39Z","timestamp":1792752039485,"version":"4.5.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,11,10]],"date-time":"2019-11-10T00:00:00Z","timestamp":1573344000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vasc Med"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:p>The left ventricular outflow tract (LVOT) velocity time integral (VTI) is an easily measured echocardiographic stroke volume index analog. Low values predict adverse outcomes in left ventricular failure. We postulate the left ventricular VTI may be a signal of right ventricular dysfunction in acute pulmonary embolism, and therefore a predictor of poor outcomes. We retrospectively reviewed echocardiograms on all Pulmonary Embolism Response Team activations at our institution at the time of pulmonary embolism diagnosis. Low LVOT VTI was defined as \u2a7d 15 cm. We examined two composite outcomes: (1) in-hospital death or cardiac arrest; and (2) shock or need for primary reperfusion therapies. Sixty-one of 188 patients (32%) had a LVOT VTI of \u2a7d 15 cm. Low VTI was associated with in-hospital death or cardiac arrest (odds ratio (OR) 6, 95% CI 2, 17.9; p = 0.0014) and shock or need for reperfusion (OR 23.3, 95% CI 6.6, 82.1; p &lt; 0.0001). In a multivariable model, LVOT VTI \u2a7d 15 remained significant for death or cardiac arrest (OR 3.48, 95% CI 1.02, 11.9; p = 0.047) and for shock or need for reperfusion (OR 8.12, 95% CI 1.62, 40.66; p = 0.011). Among intermediate\u2013high-risk patients, low VTI was the only variable associated with the composite outcome of death, cardiac arrest, shock, or need for reperfusion (OR 14, 95% CI 1.7, 118.4; p = 0.015). LVOT VTI is associated with adverse short-term outcomes in acute pulmonary embolism. The VTI may help risk stratify patients with intermediate\u2013high-risk pulmonary embolism.<\/jats:p>","DOI":"10.1177\/1358863x19880268","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T01:52:01Z","timestamp":1573437121000},"page":"133-140","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":66,"title":["Low left ventricular outflow tract velocity time integral is associated with poor outcomes in acute pulmonary embolism"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2263-9297","authenticated-orcid":false,"given":"Eugene","family":"Yuriditsky","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Cardiology, New York University School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar JL","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Department of Medicine, New York University School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel A","family":"Sibley","sequence":"additional","affiliation":[{"name":"Department of Medicine, New York University School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhe","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Population Health, Division of Biostatistics, New York University School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhilesh K","family":"Sista","sequence":"additional","affiliation":[{"name":"Department of Radiology, New York University School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Population Health, Division of Biostatistics, New York University School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Radiology, New York University School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy E","family":"Amoroso","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, New York University School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald M","family":"Goldenberg","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, New York University School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deane E","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Division of Cardiac Surgery, New York University School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Jamin","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, New York University School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shari B","family":"Brosnahan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, New York University School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas S","family":"Maldonado","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Vascular and Endovascular Surgery, New York University School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M","family":"Horowitz","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, New York University School of Medicine, New York, NY, 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