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The purpose of this study was to investigate the relationship between AS and obesity. AS was defined as high augmentation index (AIx) and low elasticity (C1, large artery elasticity; C2, small artery elasticity) in participants enrolled in the Multi-Ethnic Study of Atherosclerosis at baseline. We compared AIx, C1, and C2 by body mass index (BMI) (&lt; 25, 25\u201329.9, 30\u201339.9, \u2a7e 40 kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ) and waist\u2013hip ratio (WHR) (&lt; 0.85, 0.85\u20130.99, \u2a7e 1). The obesity\u2013AS association was tested across 10-year age intervals. Among 6177 participants (62 \u00b1 10 years old, 52% female), a significant inverse relationship was observed between obesity and AS. After adjustments for CVD risk factors, participants with a BMI &gt; 40 kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    had 5.4% lower AIx (mean difference [\u0394] = \u22120.82%; 95% CI: \u20131.10, \u20130.53), 15.4% higher C1 (\u0394 = 1.66 mL\/mmHg \u00d710; 95% CI: 1.00, 2.33), and 40.2% higher C2 (\u0394 = 1.49 mL\/mmHg \u00d7100; 95% CI: 1.15, 1.83) compared to those with a BMI &lt; 25 kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    (all p for trend &lt; 0.001). Participants with a WHR \u2a7e 1 had 5.6% higher C1 (\u2206 = 0.92 mL\/mmHg \u00d710; 95% CI: 0.47, 1.37) compared to those with a WHR &lt; 0.85. The WHR had a significant interaction with age on AIx and C2, but not with BMI; the inverse relationships of the WHR with AIx and C2 were observed only in participants &lt; 55 years between the normal (WHR &lt; 0.85) and the overweight (0.85 \u2a7d WHR &lt; 0.99) groups. Different associations of WHR and BMI with arterial stiffness among older adults should be further investigated.\n                  <\/jats:p>","DOI":"10.1177\/1358863x20918940","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T10:57:38Z","timestamp":1591095458000},"page":"309-318","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Association of obesity with arterial stiffness: The Multi-Ethnic Study of Atherosclerosis (MESA)"],"prefix":"10.1177","volume":"25","author":[{"given":"Jeongok G.","family":"Logan","sequence":"first","affiliation":[{"name":"School of Nursing, University of Virginia, Charlottesville, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyojung","family":"Kang","sequence":"additional","affiliation":[{"name":"College of Applied Health Sciences, University of Illinois at Urbana-Champaign, Champaign, IL, 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