{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:13:58Z","timestamp":1777936438067,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:00:00Z","timestamp":1608163200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vasc Med"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>The expansion of coronavirus disease 2019 (COVID-19) prompted measures of disease containment by the Italian government with a national lockdown on March 9, 2020. The purpose of this study is to evaluate the rate of hospitalization and mode of in-hospital treatment of patients with chronic limb-threatening ischemia (CLTI) before and during lockdown in the Campania region of Italy. The study population includes all patients with CLTI hospitalized in Campania over a 10-week period: 5 weeks before and 5 weeks during lockdown ( n = 453). Patients were treated medically and\/or underwent urgent revascularization and\/or major amputation of the lower extremities. Mean age was 69.2 \u00b1 10.6 years and 27.6% of the patients were women. During hospitalization, 21.9% of patients were treated medically, 78.1% underwent revascularization, and 17.4% required amputations. In the weeks during the lockdown, a reduced rate of hospitalization for CLTI was observed compared with the weeks before lockdown (25 vs 74\/100,000 inhabitants\/year; incidence rate ratio: 0.34, 95% CI 0.32\u20130.37). This effect persisted to the end of the study period. An increased amputation rate in the weeks during lockdown was observed (29.3% vs 13.4%; p &lt; 0.001). This study reports a reduced rate of CLTI-related hospitalization and an increased in-hospital amputation rate during lockdown in Campania. Ensuring appropriate treatment for patients with CLTI should be prioritized, even during disease containment measures due to the COVID-19 pandemic or other similar conditions.<\/jats:p>","DOI":"10.1177\/1358863x20977678","type":"journal-article","created":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T14:52:07Z","timestamp":1608216727000},"page":"174-179","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["A cross-sectional study evaluating hospitalization rates for chronic limb-threatening ischemia during the COVID-19 outbreak in Campania, Italy"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9763-6010","authenticated-orcid":false,"given":"Eugenio","family":"Stabile","sequence":"first","affiliation":[{"name":"Department of Advanced Biomedical Sciences, Division of Cardiology, University of Naples Federico II, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Piccolo","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, Division of Cardiology, University of Naples Federico II, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Franzese","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, Division of Cardiology, University of Naples Federico II, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giancarlo","family":"Accarino","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, AOU San Giovanni di Dio e Ruggi d\u2019Aragona, Salerno, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto Marcello","family":"Bracale","sequence":"additional","affiliation":[{"name":"Department of Public Health, Division of Vascular Surgery, University of Naples Federico II, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Cappello","sequence":"additional","affiliation":[{"name":"Division of Vascular and Endovascular Surgery, Mediterranea Centro Cuore, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Cioffi","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, Ospedale Pellegrini, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Cioppa","sequence":"additional","affiliation":[{"name":"Division of Invasive Cardiology, Clinica Montevergine, Mercogliano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adolfo","family":"Crinisio","sequence":"additional","affiliation":[{"name":"Division of Vascular and Endovascular Surgery, Clinica Salus, Battipaglia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loris","family":"Flora","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, AORN San Giuseppe Moscati, Avellino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Landino","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiac Surgery, Casa di Cura S. Michele, Maddaloni, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5764-0082","authenticated-orcid":false,"given":"Eugenio","family":"Martelli","sequence":"additional","affiliation":[{"name":"Division of Vascular and Endovascular Surgery, AORN Sant\u2019Anna e San Sebastiano, Caserta, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosario","family":"Mancusi","sequence":"additional","affiliation":[{"name":"Division of Vascular and Endovascular Surgery, Villa dei Fiori Hospital, Acerra, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaella","family":"Niola","sequence":"additional","affiliation":[{"name":"Division of Vascular and Interventional Radiology, AORN Cardarelli, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Petrosino","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, Presidio Ospedaliero \u2018San Luca\u2019, Vallo della Lucania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Razzano","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, AO San Pio, Benevento, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Ruotolo","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, AORN Cardarelli, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Salemme","sequence":"additional","affiliation":[{"name":"Division of Invasive Cardiology, Clinica Montevergine, Mercogliano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Sangiuolo","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, AORN Ospedali dei Colli, Monaldi Hospital, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianpaolo","family":"Santini","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ospedale del Mare, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Soreca","sequence":"additional","affiliation":[{"name":"Department of Radiology, AO San Pio, Benevento, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gennaro","family":"Vigliotti","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, Ospedale del Mare, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Villari","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Ospedale Sacro Cuore di Ges\u00f9, Benevento, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giampaolo","family":"Amabile","sequence":"additional","affiliation":[{"name":"Division of Vascular and Interventional Radiology, AORN Cardarelli, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele Pio","family":"Ammollo","sequence":"additional","affiliation":[{"name":"Department of Public Health, Division of Vascular Surgery, University of Naples Federico II, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danilo","family":"Barbarisi","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, AORN San Giuseppe Moscati, Avellino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonsina M","family":"Corbisiero","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiac Surgery, Casa di Cura S. 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