{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:22:08Z","timestamp":1790821328763,"version":"4.1.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vasc Med"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>Previous studies on everolimus-eluting bioresorbable vascular scaffolds (BVS) have shown promising 1-year primary patency rates in infrapopliteal arteries. Literature from large cohorts on long-term outcomes with the infrapopliteal Absorb BVS (Abbott Vascular) is lacking. The aim of this study is to pool published and unpublished data to provide a more precise estimate of the 24-month outcomes of Absorb BVS for the treatment of infrapopliteal disease. For the pooled analysis, updated original and newly collected data from three cohorts on treatment with the Absorb BVS for de novo infrapopliteal lesions were combined. The primary endpoint was freedom from restenosis. Secondary endpoints were freedom from clinically driven target lesion revascularization (CD-TLR), major amputation and survival. The pooled analysis included a total of 121 patients with 161 lesions, treated with 189 Absorb BVS in 126 limbs. The mean age of the patients was 73 years, 57% had diabetes mellitus, and 75% were classified as Rutherford\u2013Becker class 5 or 6. Of the 161 lesions, 101 (63%) were calcified and 36 (22%) were occlusions. Successful deployment was achieved with all scaffolds. Freedom from restenosis was 91.7% and 86.6% at 12 and 24 months, respectively, and freedom from CD-TLR was 97.2% and 96.6%. Major amputation occurred in 1.6% of the limbs. Overall survival was 85% at 24 months. In conclusion, this pooled analysis represents the largest reported analysis of mid-term results of the Absorb BVS for the management of chronic limb-threatening ischemia. At 24 months, the Absorb BVS was safe with promising clinical outcomes for the treatment of infrapopliteal disease.<\/jats:p>","DOI":"10.1177\/1358863x20977907","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T15:25:31Z","timestamp":1611847531000},"page":"195-199","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Mid-term outcomes of an everolimus-eluting bioresorbable vascular scaffold in patients with below-the-knee arterial disease: A pooled analysis of individual patient data"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5297-2640","authenticated-orcid":false,"given":"Eline","family":"Huizing","sequence":"first","affiliation":[{"name":"Department of Surgery, Northwest Clinics, Alkmaar, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Kum","sequence":"additional","affiliation":[{"name":"Vascular Service, Department of Surgery, Changi General Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jetty","family":"Ipema","sequence":"additional","affiliation":[{"name":"Department of Surgery, Northwest Clinics, Alkmaar, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon L","family":"Varcoe","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia"},{"name":"Department of Surgery, Prince of Wales Hospital, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atman P","family":"Shah","sequence":"additional","affiliation":[{"name":"Section of Cardiology, University of Chicago, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul PM","family":"de Vries","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Vascular Surgery, University Medical Centre Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c7a\u011fda\u015f","family":"\u00dcnl\u00fc","sequence":"additional","affiliation":[{"name":"Department of Surgery, Northwest Clinics, Alkmaar, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,1,28]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.115.003468"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1024\/0301-1526\/a000834"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2019.02.016"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.23736\/S0392-9590.19.04049-5"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/1526602816671740"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.RVI.0000058423.01661.57"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/1531003506297195"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2018.01.066"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2011.07.099"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2017.06.075"},{"key":"e_1_3_2_12_2","unstructured":"Absorb GT1\u2122: Bioresorbable Vascular Scaffold (BVS) system. Instructions for use www.accessdata.fda.gov\/cdrh_docs\/pdf15\/P150023d.pdf (2016 accessed 27 March 2020)."},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.28546"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.06.005"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/1526602820922524"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/1708538120954947."},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/1526602818799736"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.2002.1801"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/1538574416689429"},{"key":"e_1_3_2_20_2","first-page":"1","article-title":"Primary everolimus-eluting stenting versus balloon angioplasty with bailout bare metal stenting of long infrapopliteal lesions for treatment of critical limb ischemia","volume":"18","author":"Karnabatidis D","unstructured":"Karnabatidis D, Spiliopoulos S, Diamantopoulos A, et al. Primary everolimus-eluting stenting versus balloon angioplasty with bailout bare metal stenting of long infrapopliteal lesions for treatment of critical limb ischemia. J Endovasc Ther 2011; 18: 1\u201312.","journal-title":"J Endovasc Ther 2011"},{"issue":"5","key":"e_1_3_2_21_2","first-page":"677","article-title":"Drug-eluting stents remain the golden standard for below-the-knee occlusive disease","volume":"57","author":"Mosquera Arochena NJ.","year":"2016","unstructured":"Mosquera Arochena NJ. Drug-eluting stents remain the golden standard for below-the-knee occlusive disease. J Cardiovas Surg (Torino) 2016; 57(5): 677\u2013682.","journal-title":"J Cardiovas Surg (Torino)"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2009.05.031"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.04.035"},{"key":"e_1_3_2_24_2","unstructured":"ClinicalTrials.gov. 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