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Optimized medical care and risk factor modification in addition to revascularization could reduce the incidence of cardiovascular events and major adverse limb events, improving patients\u2019 quality of life and promising higher survival rates. Adequate adherence to cardioprotective medications, including antithrombotic therapy (e.g., antiplatelets, anticoagulants), cholesterol-lowering agents (e.g., statins, proprotein convertase subtilisin\/kexin type 9 (PCSK9) inhibitors), angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs), and smoking cessation should be strongly encouraged for patients with CLI. This review examines these guideline-recommended therapies in terms of cardiovascular and limb-related risk reduction in patients with CLI.<\/jats:p>","DOI":"10.1177\/1358863x20987612","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T16:52:59Z","timestamp":1613839979000},"page":"210-224","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Medical therapy for cardiovascular and limb-related risk reduction in critical limb ischemia"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1942-911X","authenticated-orcid":false,"given":"Stefanos","family":"Giannopoulos","sequence":"first","affiliation":[{"name":"Division of Cardiology, Rocky Mountain Regional VA Medical Center, University of Colorado, Denver, CO, 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