{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:14:05Z","timestamp":1777936445370,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T00:00:00Z","timestamp":1624579200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vasc Med"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Vena cava filters have been used as a primary means to prevent symptomatic pulmonary embolism (PE) in trauma patients who cannot be anticoagulated after severe injury, but the economic implications for this practice remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Using a healthcare system perspective to analyze the a priori primary outcome of the da Vinci trial, we report the cost-effectiveness of using vena cava filters as a primary means to prevent PE in patients who have contraindications to prophylactic anticoagulation after major trauma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of the 240 patients enrolled, complete, prospectively collected, hospital cost data during the entire hospital stay \u2212 including costs for the filter, medical\/nursing\/allied health staff, medical supplies, pathology tests, and radiological imaging \u2212 were available in 223 patients (93%). Patients allocated to the filter group ( n = 114) were associated with a reduced risk of PE (0.9%) compared to those in the control group ( n = 109, 5.5%; p = 0.048); and the filter\u2019s benefit was more pronounced among those who could not be anticoagulated within 7 days (filter: 0% vs control: 16%, Bonferroni-corrected p = 0.02). Overall, the cost needed to prevent one PE was high (AUD $379,760), but among those who could not be anticoagulated within 7 days, the costs to prevent one PE (AUD $36,156; ~ USD $26,032) and gain one quality-adjusted life-year (AUD $30,903; ~ USD $22,250) were substantially lower.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The cost of using a vena cava filter to prevent PE for those who have contraindications to prophylactic anticoagulation within 3 days of injury is prohibitive, unless such contraindications remain for longer than 7 days. (Australian New Zealand Clinical Trials Registry no.: ACTRN12614000963628)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1358863x211023559","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T05:32:20Z","timestamp":1624599140000},"page":"641-647","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Cost-effectiveness of early placement of vena cava filters to prevent symptomatic pulmonary embolism in patients with contraindications to prophylactic anticoagulant"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6705-6004","authenticated-orcid":false,"given":"Kwok M","family":"Ho","sequence":"first","affiliation":[{"name":"Department of Intensive Care Medicine, Royal Perth Hospital, Perth, WA, Australia"},{"name":"The University of Western Australia School of Medicine, Perth, WA, Australia"},{"name":"Murdoch University School of Veterinary & Life Sciences, Perth, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick B","family":"Rogers","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Pennsylvania, Lancaster, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudhakar","family":"Rao","sequence":"additional","affiliation":[{"name":"State Trauma Unit, Royal Perth Hospital, Perth, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"Chamberlain","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, Royal Perth Hospital, Perth, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Geelhoed","sequence":"additional","affiliation":[{"name":"The University of Western Australia School of Allied Health, Perth, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,6,25]]},"reference":[{"key":"bibr1-1358863X211023559","unstructured":"Australian Commission on Safety and Quality in Health Care. 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