{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:17:45Z","timestamp":1778617065138,"version":"3.51.4"},"reference-count":54,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T00:00:00Z","timestamp":1639958400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T00:00:00Z","timestamp":1639958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vasc Med"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>\n                    Intermittent claudication (IC) is a classic symptom of peripheral artery disease, with first line treatment being supervised exercise therapy (SET). Despite this, SET is frequently underutilised, and adherence is often poor. An alternative option are home-based exercise programmes (HBEP). Although HBEPs are well tolerated, to the authors\u2019 knowledge, no research has assessed their safety. The aim of this review was to assess the safety of HBEPs in people living with IC. We performed an electronic search of the MEDLINE, CINAHL, and Cochrane Library databases. The main parameter of interest was complication rate, calculated as the number of related adverse events per patient-hours. Subanalysis was undertaken to determine differences in safety for studies that did and did not include pre-exercise cardiac screening, and for studies with exercise at low, moderate, and high levels of claudication pain. Our search strategy identified 8693 results, of which 27 studies were included for full review. Studies included 1642 participants completing 147,810 patient-hours of home-based exercise. Four related adverse events were reported, three of which were cardiac in origin, giving an all-cause complication rate of one event per 36,953 patient-hours. Three of these events occurred following exercise to high levels of claudication pain, and one occurred with pain-free exercise. One event occured in a study without cardiac screening. Based on the low number of related adverse events, HBEPs appear to be a safe method of exercise prescription for people with IC. Our results strengthen the rationale for providing alternative exercise options for this population.\n                    <jats:bold>PROSPERO Registration No.: CRD42021254581<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1177\/1358863x211060388","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T00:19:15Z","timestamp":1640045955000},"page":"186-192","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Safety of home-based exercise for people with intermittent claudication: A systematic review"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9880-655X","authenticated-orcid":false,"given":"Alexander","family":"Waddell","sequence":"first","affiliation":[{"name":"Centre for Sport, Exercise and Life Sciences, Institute of Health and Wellbeing, Coventry University, Coventry, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2717-7485","authenticated-orcid":false,"given":"Sally","family":"Seed","sequence":"additional","affiliation":[{"name":"School of Sport and Health Sciences, University of Central Lancashire, Preston, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R","family":"Broom","sequence":"additional","affiliation":[{"name":"Centre for Sport, Exercise and Life Sciences, Institute of Health and Wellbeing, Coventry University, Coventry, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8963-9107","authenticated-orcid":false,"given":"Gordon","family":"McGregor","sequence":"additional","affiliation":[{"name":"Centre for Sport, Exercise and Life Sciences, Institute of Health and Wellbeing, Coventry University, Coventry, UK"},{"name":"Department of Cardiopulmonary Rehabilitation, Centre for Exercise &amp; Health, University Hospitals Coventry &amp; Warwickshire NHS Trust, Coventry, UK"},{"name":"Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0422-6843","authenticated-orcid":false,"given":"Stefan T","family":"Birkett","sequence":"additional","affiliation":[{"name":"School of Sport and Health Sciences, University of Central Lancashire, Preston, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5745-2564","authenticated-orcid":false,"given":"Amy E","family":"Harwood","sequence":"additional","affiliation":[{"name":"Centre for Sport, Exercise and Life Sciences, Institute of Health and Wellbeing, Coventry University, Coventry, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,12,20]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(19)30255-4"},{"key":"e_1_3_2_3_2","first-page":"645","article-title":"The diagnosis of ischaemic heart pain and intermittent claudication in field surveys","volume":"27","author":"Rose GA","year":"1962","unstructured":"Rose GA. The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. Bull World Health Organ 1962; 27: 645\u2013658.","journal-title":"Bull World Health Organ"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000002526"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X07084911"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.4.453"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/0003319706293114"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.11.007"},{"key":"e_1_3_2_9_2","unstructured":"National Institute for Health and Care Excellence. Peripheral arterial disease: diagnosis and management. 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