{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:23:14Z","timestamp":1790716994967,"version":"4.1.0"},"reference-count":45,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:00:00Z","timestamp":1681084800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sparbanksstiftelsen Nya"},{"DOI":"10.13039\/501100009612","name":"landstinget v\u00e4stmanland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009612","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Swedish Medical Association"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vasc Med"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Patients with peripheral vascular disease (PVD) are often underdiagnosed and undertreated. Nocturnal nondipping blood pressure (BP) pattern, as diagnosed by ambulatory BP monitoring (ABPM), is associated with increased cardiovascular risk, but has not been studied in patients with PVD. We aimed to investigate if a nondipping BP pattern predicts cardiovascular events or all-cause death in outpatients with PVD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Consecutive outpatients with carotid or lower-extremity PVD were examined with 24-hour ABPM ( n = 396). Nondipping was defined as a &lt; 10% fall in systolic BP level during night-time. We used Cox regression models adjusting for potential confounders. We also evaluated the incremental prognostic value of dipping status in the COPART risk score. Our primary composite outcome was cardiovascular events or all-cause death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In the cohort (mean age 70; 40% women), 137 events occurred during a 5.1-year median follow-up; incident rate of 7.35 events per 100 person-years. Nondipping was significantly associated with outcome (hazard ratio 1.55, 95% CI 1.07\u20132.26, p = 0.021) in a fully adjusted model. When adding nondipping to the risk markers in the COPART risk score, the model fit significantly improved (\u03c7\n                      <jats:sup>2<\/jats:sup>\n                      7.91, p &lt; 0.005) and the C-statistic increased from 0.65 to 0.67.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In a cohort of outpatients with PVD, nondipping was an independent risk factor for future cardiovascular events or mortality and seemed to be a strong predictor in patients with carotid artery disease but not in lower-extremity PVD. Additional studies are needed to evaluate the clinical utility of ABPM for improved prevention in these high-risk patients. (ClinicalTrials.gov Identifier: NCT01452165)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1358863x231161655","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T07:51:59Z","timestamp":1681113119000},"page":"274-281","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Nondipping blood pressure pattern predicts cardiovascular events and mortality in patients with atherosclerotic peripheral vascular disease"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1444-2515","authenticated-orcid":false,"given":"Nina","family":"Dahle","sequence":"first","affiliation":[{"name":"Center for Clinical Research Dalarna, Uppsala University, Falun, Sweden"},{"name":"Primary Health Care Center Britsarvet-Grycksbo, County of Dalarna, Falun, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"\u00c4rnl\u00f6v","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Division of Family Medicine and Primary Care, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden"},{"name":"School of Health and Social Studies, Dalarna University, Falun, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"Leppert","sequence":"additional","affiliation":[{"name":"Center for Clinical Research, Uppsala University, V\u00e4stmanland County Hospital, V\u00e4ster\u00e5s, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e4r","family":"Hedberg","sequence":"additional","affiliation":[{"name":"Center for Clinical Research, Uppsala University, V\u00e4stmanland County Hospital, V\u00e4ster\u00e5s, Sweden"},{"name":"Department of Clinical Physiology, V\u00e4stmanland County Hospital, V\u00e4ster\u00e5s, 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