{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T10:57:10Z","timestamp":1793876230231,"version":"4.7.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["5UL1TR002243-03"],"award-info":[{"award-number":["5UL1TR002243-03"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K23 HL151871"],"award-info":[{"award-number":["K23 HL151871"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL157378"],"award-info":[{"award-number":["R01 HL157378"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013317","name":"Lipedema Foundation","doi-asserted-by":"publisher","award":["LF Award 12"],"award-info":[{"award-number":["LF Award 12"]}],"id":[{"id":"10.13039\/100013317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013317","name":"Lipedema Foundation","doi-asserted-by":"publisher","award":["LF Award LF30-B"],"award-info":[{"award-number":["LF Award LF30-B"]}],"id":[{"id":"10.13039\/100013317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013317","name":"Lipedema Foundation","doi-asserted-by":"publisher","award":["Postdoctoral Research Fellowship"],"award-info":[{"award-number":["Postdoctoral Research Fellowship"]}],"id":[{"id":"10.13039\/100013317","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vasc Med"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>National survey data exploring the patient experience with lipedema are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted national surveys from 2016 to 2022 of women with lipedema as well as female controls. Surveys collected information on symptomatology, pain, and therapies. We performed logistic regression comparing symptoms among those with lipedema versus controls adjusting for age and BMI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 707 women with lipedema and 216 controls completed the surveys. Those with lipedema had a mean age of 48.6 years and mean BMI of 40.9 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . Lipedema symptom onset occurred frequently at puberty (48.0%) or pregnancy (41.2%). Compared to controls, women with lipedema were more likely to report leg swelling in heat (odds ratio [OR], 66.82; 95% CI, 33.04\u2013135.12; p &lt; 0.0001), easy bruising (OR, 26.23; 95% CI, 15.58\u201344.17; p &lt; 0.0001), altered gait (OR, 15.54; 95% CI, 7.58\u201331.96; p &lt; 0.0001), flu-like symptoms (OR, 12.99; 95% CI, 4.27\u201339.49; p &lt; 0.0001), joint hypermobility (OR, 12.88; 95% CI, 6.68\u201324.81; p &lt; 0.0001), cool skin (OR, 12.21; 95% CI, 5.20\u201328.69; p &lt; 0.0001), varicose veins (OR, 11.29; 95% CI, 6.71\u201318.99; p &lt; 0.0001), and fatigue (OR, 9.59; 95% CI, 6.10\u201315.09; p &lt; 0.0001). Additionally, 70.3% had upper arm involvement, 21.2% reported foot swelling, and 16.6% reported foot pain. Most (52.2%) reported no symptom improvement with diet or exercise. Common therapies used included compression therapy (45.0%), gastric bypass (15.7%), and lower-extremity liposuction (14.0%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In a large, national, symptom survey, women with lipedema reported excess pain, swelling, and fat in the legs along with numerous symptoms beyond those classically described. Symptom responses to common therapies remain understudied.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1358863x231202769","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T13:17:02Z","timestamp":1697462222000},"page":"36-41","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":39,"title":["National survey of patient symptoms and therapies among 707 women with a lipedema phenotype in the United States"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6243-3432","authenticated-orcid":false,"given":"Aaron W","family":"Aday","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula MC","family":"Donahue","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, USA"},{"name":"Dayani Center for Health and Wellness, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Garza","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa N","family":"Crain","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niral J","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Neurology, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A","family":"Beasley","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L","family":"Herbst","sequence":"additional","affiliation":[{"name":"Total Lipedema Care, Beverly Hills, CA and Tucson, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8332-8439","authenticated-orcid":false,"given":"Joshua A","family":"Beckman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon L","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA"},{"name":"Department of Pediatrics, Division of Pediatric Neurology, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Pridmore","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheau-Chiann","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manus J","family":"Donahue","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA"},{"name":"Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachelle","family":"Crescenzi","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA"},{"name":"Department of Pediatrics, Division of Pediatric Neurology, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,10,16]]},"reference":[{"key":"bibr1-1358863X231202769","doi-asserted-by":"publisher","DOI":"10.1177\/02683555211015887"},{"key":"bibr2-1358863X231202769","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-34-5-1243"},{"key":"bibr3-1358863X231202769","doi-asserted-by":"publisher","DOI":"10.1515\/hmbci-2017-0076"},{"key":"bibr4-1358863X231202769","first-page":"178","volume":"44","author":"Szolnoky 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