{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:42:22Z","timestamp":1787164942666,"version":"build-2736575974"},"reference-count":30,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:00:00Z","timestamp":1707436800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:00:00Z","timestamp":1707436800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vasc Med"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>For primary Raynaud phenomenon (PRP), an otherwise unexplained vasospastic disposition is assumed. To test the hypothesis of an additional involvement of distinct ultrastructural microvascular alterations, we compared the nailfold capillary pattern of patients with PRP and healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 120 patients with PRP (with a median duration of vasospastic symptoms of 60 [IQR: 3\u2013120] months) were compared against 125 controls. In both groups, nailfold capillaroscopy was performed to record the presence of dilatations, capillary edema, tortuous capillaries, ramifications, hemorrhages, and reduced capillary density and to determine a semiquantitative rating score. Further, the capacity of finger skin rewarming was investigated by performing infrared thermography in combination with cold provocation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Unspecific morphologic alterations were found in both, PRP, such as controls, whereby the risk for PRP was four times as high in the presence of capillary dilations (CI: 2.3\u20137.6) and five times as high if capillary density was reduced (CI: 1.9\u201313.5). Capillary density correlated with thermoregulatory capacity in both hands in the PRP group, but not in controls. In addition, a negative correlation between the microangiopathy score and the percentage degree of rewarming in both hands was found for patients with PRP only.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We found specific differences within the microvascular architecture between patients with PRP and controls. As a conclusion, PRP may not be an entirely benign vasospastic phenomenon, but might be associated with subtle microcirculatory vasculopathy. In addition, we suggest that the implementation of a scoring system might serve as guidance in the diagnostic process at least of patients with long-standing PRP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1358863x231223523","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T05:46:56Z","timestamp":1707457616000},"page":"200-207","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Capillaroscopic differences between primary Raynaud phenomenon and healthy controls indicate potential microangiopathic involvement in benign vasospasms"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7825-1254","authenticated-orcid":false,"given":"Sophie","family":"Brunner-Ziegler","sequence":"first","affiliation":[{"name":"Department of Internal Medicine II, Division of Angiology, Medical University of Vienna, Vienna, Austria"},{"name":"Current: Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5422-3889","authenticated-orcid":false,"given":"Eva","family":"Dassler","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Division of Angiology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Division of Angiology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Pratscher","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Division of Angiology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaus Franz-Ferdinand Maria","family":"Forstner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Division of Angiology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renate","family":"Koppensteiner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Division of Angiology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Schlager","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Division of Angiology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Jilma","sequence":"additional","affiliation":[{"name":"Current: Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,2,9]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex199"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.5152\/eurjrheum.2020.19124"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.38923"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2004.06.006"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24038"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.38098"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.121089"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2018-000782"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11060981"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex460"},{"issue":"126","key":"e_1_3_2_12_2","first-page":"150","article-title":"Nailfold capillaroscopy in Sj\u00f6gren\u2019s syndrome: A systematic literature review and standardised interpretation","volume":"38","author":"Melsens K","year":"2020","unstructured":"Melsens K, Leone MC, Paolino S, et al Nailfold capillaroscopy in Sj\u00f6gren\u2019s syndrome: A systematic literature review and standardised interpretation. Clin Exp Rheumatol 2020; 38(suppl 126): 150\u2013157.","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-021-02551-6"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2022.104367"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.079756"},{"key":"e_1_3_2_16_2","first-page":"155","article-title":"Nailfold videocapillaroscopy assessment of microvascular damage in systemic sclerosis","volume":"27","author":"Cutolo M","year":"2000","unstructured":"Cutolo M, Sulli A, Pizzorni C, Accardo S. Nailfold videocapillaroscopy assessment of microvascular damage in systemic sclerosis. J Rheumatol 2000; 27: 155\u2013160.","journal-title":"J Rheumatol"},{"key":"e_1_3_2_17_2","first-page":"195","article-title":"Microvascular abnormalities as possible predictors of disease subset in Raynaud\u2019s phenomenon and early connective tissue disease","volume":"1","author":"Maricq HR","year":"1983","unstructured":"Maricq HR, Harper FE, Khan MM, et al Microvascular abnormalities as possible predictors of disease subset in Raynaud\u2019s phenomenon and early connective tissue disease. Clin Exp Rheumatol 1983; 1: 195\u2013205.","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_3_2_18_2","first-page":"841","article-title":"Computerized nailfold video capillaroscopy\u2014A new tool for assessment of Raynaud\u2019s phenomenon","volume":"32","author":"Anderson ME","year":"2005","unstructured":"Anderson ME, Allen PD, Moore T, et al Computerized nailfold video capillaroscopy\u2014A new tool for assessment of Raynaud\u2019s phenomenon. J Rheumatol 2005; 32: 841\u2013848.","journal-title":"J Rheumatol"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2005.01.001"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/35.11.1127"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/39.5.506"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1024\/0301-1526\/a000159"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.23555"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1995.sp020725"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2022-002449"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2022.104361"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.idoj_80_22"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00393-014-1359-2"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/occmed\/51.2.075"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-017-1214-2"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/40.12.1431"}],"container-title":["Vascular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1358863X231223523","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1358863X231223523","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1358863X231223523","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:34:36Z","timestamp":1777692876000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1358863X231223523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,9]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1177\/1358863X231223523"],"URL":"https:\/\/doi.org\/10.1177\/1358863x231223523","relation":{},"ISSN":["1358-863X","1477-0377"],"issn-type":[{"value":"1358-863X","type":"print"},{"value":"1477-0377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,9]]}}}