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Though single-component interventions targeting smoking cessation, exercise, or medication adherence show some efficacy, comprehensive multicomponent interventions are vital for addressing the complexity of PAD management. This review systematically synthesized multicomponent interventions for patients with PAD. A systematic search was conducted in Embase, MEDLINE, Cochrane Library, APA PsycINFO, CINAHL, Web of Science Core Collection, ProQuest, and Google Scholar to identify primary research describing multicomponent interventions supporting PAD treatment adherence, published between 2007 and 2024. A narrative synthesis was reported using the Template for Intervention Description and Replication (TIDieR) checklist and the behavioral change techniques (BCT) taxonomy. Out of 15 studies (2462 patients, 60.4% men) included in this review, only two addressed all guideline-recommended treatment aspects. Key intervention components included structured exercise (12\/15) and education programs (10\/15). Most interventions were delivered by multidisciplinary teams in hospital settings over 3 months. Only one study employed behavioral theory in its development, and most interventions (13\/15) focused on the BCT \u2018instructions on how to perform a behavior\u2019 rather than diverse BCTs. No interventions significantly increased adherence to all PAD therapies. Few studies measured the intervention\u2019s impact on adherence, making it difficult to determine effective intervention characteristics. Most interventions lacked behavioral science approaches and were not designed to address specific adherence determinants. Future interventions should incorporate these elements to effectively address patients\u2019 needs.\n                    <jats:bold>Open Science Framework Registry ID: osf.io\/7xqzj<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1177\/1358863x251315071","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T09:42:02Z","timestamp":1741858922000},"page":"343-352","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Multicomponent interventions designed to support adherence to guideline-recommended therapy in patients with peripheral artery disease: A scoping review"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6700-1687","authenticated-orcid":false,"given":"Smaragda","family":"Lampridou","sequence":"first","affiliation":[{"name":"Vascular Surgery Department, Imperial College Healthcare NHS Trust, London, UK"},{"name":"Department of Surgery &amp; Cancer, Faculty of Medicine, Imperial College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania","family":"Domun","sequence":"additional","affiliation":[{"name":"Department of Surgery &amp; Cancer, Faculty of Medicine, Imperial College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3454-1556","authenticated-orcid":false,"given":"Javiera","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Department of Surgery &amp; Cancer, Faculty of Medicine, Imperial College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachael","family":"Lear","sequence":"additional","affiliation":[{"name":"Department of Surgery &amp; Cancer, Faculty of Medicine, Imperial College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alun Huw","family":"Davies","sequence":"additional","affiliation":[{"name":"Vascular Surgery Department, Imperial College Healthcare NHS Trust, London, UK"},{"name":"Department of Surgery &amp; Cancer, Faculty of Medicine, Imperial College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Wells","sequence":"additional","affiliation":[{"name":"Department of Surgery &amp; Cancer, Faculty of Medicine, Imperial College London, London, UK"},{"name":"Nursing Directorate, Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaby","family":"Judah","sequence":"additional","affiliation":[{"name":"Department of Surgery &amp; Cancer, Faculty of Medicine, Imperial College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"key":"e_1_3_3_2_2","article-title":"Peripheral artery disease","volume":"360","author":"Morley RL","year":"2018","unstructured":"Morley RL, Sharma A, Horsch AD, Hinchliffe RJ. 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