{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:21:49Z","timestamp":1793384509718,"version":"4.5.0"},"reference-count":63,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the Health and Care Research Wales funded National Cardiovascular Research Network, Wales"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vasc Med"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Sedentary behavior, specifically an acute bout of prolonged uninterrupted sitting, is associated with heightened cardiovascular disease (CVD) risk, with increased arterial stiffness (AS) being implicated as a principal pathophysiological mechanism. The current systematic review, with meta-analysis, aimed to consolidate the AS response to (1) prolonged uninterrupted sitting and (2) interrupted sitting, as assessed by central and peripheral pulse wave velocity (PWV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      In total, 326 articles were identified, of which 11 and seven met the inclusion criteria for objectives (1) and (2), respectively. Mean differences (MD) and 95% CI were calculated for all trials using a three-level random-effects model, with restricted maximum likelihood (REML) estimation. The amount of heterogeneity was estimated using Cochran\u2019s Q and Higgins\u2019s\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      tests.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      (1) Prolonged uninterrupted sitting resulted in a significant increase in carotid-femoral (cf) PWV (MD = 0.184 m\/s, 95% CI = 0.098 to 0.270,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.0003). (2) Interrupting bouts of prolonged sitting resulted in a significant increase in cf-PWV (MD = 0.127 m\/s, 95% CI = 0.044 to 0.209,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.0026) that was lower compared to the uninterrupted sitting.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>An acute bout of uninterrupted sitting appears to increase cf-PWV; although interrupting prolonged sitting with brief physical activity is beneficial, it does not fully mitigate the response.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1358863x251333672","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T03:14:53Z","timestamp":1750821293000},"page":"403-413","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["The effects of acute exposure to prolonged sitting, with and without interruption, on central and peripheral pulse wave velocity: A systematic review and meta-analysis"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4242-1714","authenticated-orcid":false,"given":"Arsalan","family":"Moinuddin","sequence":"first","affiliation":[{"name":"School of Education and Science, University of Gloucestershire, Gloucester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Paterson","sequence":"additional","affiliation":[{"name":"School of Population Sciences, Bristol Medical School, University of Bristol, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Turner","sequence":"additional","affiliation":[{"name":"School of Education and Science, University of Gloucestershire, Gloucester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keeron","family":"Stone","sequence":"additional","affiliation":[{"name":"Cardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel JE","family":"Lucas","sequence":"additional","affiliation":[{"name":"School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Cardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Fryer","sequence":"additional","affiliation":[{"name":"School of Education and Science, University of Gloucestershire, Gloucester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12966-017-0525-8"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.019620"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/1747493018798535"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-020-01325-5"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000002763"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000132474.50966.DA"},{"key":"e_1_3_2_8_2","first-page":"307","article-title":"Effect of prior moderate aerobic exercise to prolonged sitting on peripheral and central cardiovascular measures in young women","volume":"11","author":"Alansare AB","year":"2024","unstructured":"Alansare AB, Alotaibi RT, Albarrati AM, et al. 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