{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T10:17:17Z","timestamp":1792491437695,"version":"4.5.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vasc Med"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>This study aimed to evaluate the incidence and risk factors for progression to chronic limb-threatening ischemia (CLTI) in patients with peripheral artery disease (PAD) and de novo claudication who underwent endovascular therapy (EVT), particularly femoropopliteal intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 338 limbs from consecutive patients with de novo claudication who received their first EVT were evaluated. The primary endpoint was progression to CLTI, assessed using the Kaplan\u2013Meier estimate and hazard ratios (HRs) calculated via Cox regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>CLTI developed in 21 of 196 femoropopliteal interventions and four of 142 aortoiliac interventions. The median time from initial femoropopliteal intervention to CLTI onset was 2.4 years. Limbs treated with femoropopliteal intervention progressed to CLTI more often than those treated with aortoiliac intervention (estimated 10-year incidence: 15.3% vs 8.6%). Univariate analysis identified chronic kidney disease with or without hemodialysis (HR: 6.43; 95% CI: 2.02\u201324.1, HR: 3.13; 95% CI: 1.02\u201311.6), chronic heart failure (HR: 2.71; 95% CI: 1.14\u20136.55), severe calcification (HR: 2.98; 95% CI: 1.06\u20137.39), P2\u20133 segment intervention (HR: 4.72; 95% CI: 1.52\u201312.4), and poor infrapopliteal runoff (HR: 15.1; 95% CI: 5.06\u201364.7) as risk factors. Multivariate analysis showed poor infrapopliteal runoff as an independent predictor (HR: 11.2; 95% CI: 3.56\u201349.3).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Progression to CLTI following femoropopliteal intervention in patients with claudication is influenced by comorbidities, vessel calcification, involvement of the P2\u20133 segment, and especially poor infrapopliteal runoff, regardless of EVT strategy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1358863x251349771","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T11:28:08Z","timestamp":1752665288000},"page":"568-576","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Risk factors for progression to chronic limb-threatening ischemia after endovascular therapy in patients with claudication"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3854-7760","authenticated-orcid":false,"given":"Keisuke","family":"Shoji","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Kyoto Chubu Medical Center, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michitaka","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Kyoto Chubu Medical Center, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiori","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Kyoto Chubu Medical Center, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukinori","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Kyoto Chubu Medical Center, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naotoshi","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Kyoto Chubu Medical Center, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Kyoto Chubu Medical Center, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsuya","family":"Keira","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Kyoto Chubu Medical Center, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Tatsumi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Kyoto Chubu Medical Center, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,7,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2023.08.067"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a1840"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800810110"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2015.10.022"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2001.119749"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2021.02.045"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2020.10.004"},{"key":"e_1_3_3_9_2","article-title":"Early peripheral vascular interventions for claudication are associated with higher rates of late interventions and progression to chronic limb threatening ischemia","volume":"77","author":"Sorber R","year":"2023","unstructured":"Sorber R, Dun C, Kawaji Q, et al Early peripheral vascular interventions for claudication are associated with higher rates of late interventions and progression to chronic limb threatening ischemia. J Vasc Surg 2023; 77: 836\u2013847.e3.","journal-title":"J Vasc Surg"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/17085381211039668"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjqcco\/qcw057"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.121.011506"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2019.09.001"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30183-3"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11060493"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2023.11.023"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.05.001"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/15266028221134886"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2011.11.025"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/15266028231197983"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.31291"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X251367756"}],"container-title":["Vascular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1358863X251349771","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1358863X251349771","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1358863X251349771","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:36:08Z","timestamp":1777692968000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1358863X251349771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,16]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1177\/1358863X251349771"],"URL":"https:\/\/doi.org\/10.1177\/1358863x251349771","relation":{},"ISSN":["1358-863X","1477-0377"],"issn-type":[{"value":"1358-863X","type":"print"},{"value":"1477-0377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,16]]}}}