{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:09:55Z","timestamp":1790352595859,"version":"4.1.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vasc Med"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    This study aimed to assess the impact of active malignancy on outcomes in patients undergoing revascularization for acute limb ischemia (ALI), focusing on mortality, limb salvage, and patency loss.\n                    <jats:bold>Methods:<\/jats:bold>\n                    We conducted a retrospective analysis of consecutive patients with ALI who underwent lower-limb revascularization over a 7-year period. Patients were stratified into two groups based on the presence of active malignancy at ALI diagnosis. Kaplan\u2013Meier analysis was used to assess survival, limb salvage, and freedom from reocclusion. Cox proportional hazards models were applied to identify independent predictors of mortality, major amputation, and reocclusion.\n                    <jats:bold>Results:<\/jats:bold>\n                    A total of 296 patients were included, with a mean age of 76.2 \u00b1 12.6 years; 62.8% were men. Most occlusions involved the femoropopliteal segment (57.8%). Thirty-eight patients (12.8%) had active malignancy. Baseline characteristics, interventions, and 30-day outcomes were similar between groups. Over a median follow up of 29.8 \u00b1 24.6 months, 140 deaths (47.3%) were recorded. Patients with malignancy had significantly worse survival (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.005), but similar rates of limb salvage and freedom from reocclusion. In multivariable analysis, active malignancy was independently associated with higher mortality (OR 3.321, 95% CI 1.310\u20138.418,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.01), but not with limb salvage or patency loss.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Active malignancy is associated with increased mid- and long-term mortality in patients with ALI, yet limb-related outcomes remain comparable to nononcological patients. Aggressive revascularization strategies should not be withheld solely due to malignancy when clinically appropriate.\n                  <\/jats:p>","DOI":"10.1177\/1358863x251351907","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T07:19:39Z","timestamp":1753341579000},"page":"683-693","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Active malignancy does not affect limb salvage and reocclusion in patients with acute limb ischemia: A single-center experience"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6619-0159","authenticated-orcid":false,"given":"Edoardo","family":"Pasqui","sequence":"first","affiliation":[{"name":"Department of Medicine, Surgery and Neuroscience, Vascular Surgery Unit, University of Siena, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira","family":"Bucelli","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Neuroscience, Vascular Surgery Unit, University of Siena, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Pasquetti","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Neuroscience, Vascular Surgery Unit, University of Siena, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Molino","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Neuroscience, Vascular Surgery Unit, University of Siena, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Ferraro","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Neuroscience, Vascular Surgery Unit, University of Siena, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianmarco","family":"de Donato","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Neuroscience, Vascular Surgery Unit, University of Siena, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2019.09.006"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1006054"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-0998-4204"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2015.10.004"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16112082"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/1753944716687517"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semvascsurg.2018.12.008"},{"key":"e_1_3_3_9_2","first-page":"240","article-title":"Optimal activated clotting time during peripheral artery endovascular procedures: Cutting the gordian knot","volume":"64","author":"Patrone L","year":"2023","unstructured":"Patrone L, Pasqui E, Sheahan K, et al Optimal activated clotting time during peripheral artery endovascular procedures: Cutting the gordian knot. J Cardiovasc Surg (Torino) 2023; 64: 240\u2013246.","journal-title":"J Cardiovasc Surg (Torino)"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2015.06.223"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1991.9.2.286"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2022.01.004"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvsvf.2021.10.019"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2021.03.058"},{"key":"e_1_3_3_15_2","first-page":"233","article-title":"Endovascular thrombectomy devices for acute limb ischemia management","volume":"64","author":"Isernia G","year":"2023","unstructured":"Isernia G, Pasqui E, de Donato G, et al Endovascular thrombectomy devices for acute limb ischemia management. J Cardiovasc Surg (Torino) 2023; 64: 233\u2013239.","journal-title":"J Cardiovasc Surg (Torino)"},{"key":"e_1_3_3_16_2","first-page":"247","article-title":"Mechanical thrombectomy in acute limb ischemia: ad Interim results of the INDIAN UP Trial","volume":"64","author":"de Donato G","year":"2023","unstructured":"de Donato G, Pasqui E, Ruffino MA, et al; INDIAN UP Trial group. Mechanical thrombectomy in acute limb ischemia: ad Interim results of the INDIAN UP Trial. J Cardiovasc Surg (Torino) 2023; 64: 247\u2013254.","journal-title":"J Cardiovasc Surg (Torino)"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2021.01.004"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2019.05.031"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/17085381211010012"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10194343"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X251371015"}],"container-title":["Vascular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1358863X251351907","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1358863X251351907","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1358863X251351907","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:36:10Z","timestamp":1777692970000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1358863X251351907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,24]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1177\/1358863X251351907"],"URL":"https:\/\/doi.org\/10.1177\/1358863x251351907","relation":{},"ISSN":["1358-863X","1477-0377"],"issn-type":[{"value":"1358-863X","type":"print"},{"value":"1477-0377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,24]]}}}