{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T19:17:57Z","timestamp":1780427877120,"version":"3.54.1"},"reference-count":22,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001810","name":"research promotion foundation","doi-asserted-by":"publisher","award":["41\/50\u03a0E-2002"],"award-info":[{"award-number":["41\/50\u03a0E-2002"]}],"id":[{"id":"10.13039\/501100001810","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cardiovascular Disease Educational and Research Trust, UK"},{"name":"Ministry of Health, Government of Cyprus, Nicosia, Cyprus"},{"name":"AG Leventis Foundation"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vasc Med"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The aims were to determine the 10-year risk of atherosclerotic cardiovascular disease (ASCVD) in individuals free from ASCVD (a) in the presence of carotid bifurcation plaques (CBP) &lt; 3-mm thick and \u2a7e 3 mm in comparison to a normal vessel wall and (b) the risk modulation in the presence or absence of additional common femoral bifurcations with plaques (CFBP) in a cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 1000 subjects aged 58.4 \u00b1 10.5 years, free from ASCVD, were followed up for 15.2 \u00b1 4.9 years (mean \u00b1 SD). The primary endpoint was a composite of first time fatal or nonfatal 10-year ASCVD events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The 10-year risk of ASCVD was 6% in the absence of carotid plaques; 10% in the presence of unilateral and 23% in the presence of bilateral &lt; 3-mm plaques (adjusted hazard ratio [HR] 1.65 [95% CI 1.11\u20132.47] and 2.03 [95% CI 1.32\u20133.00], respectively); and 29% for unilateral and 63% for bilateral 3\u20135 mm plaques (adjusted HR 2.40 [95% CI 1.41\u20134.09] and 3.78 [95% CI 1.77\u20138.06], respectively). In those with unilateral or bilateral &lt; 3-mm CBP in the presence of two CFBP, the 10-year risk of ASCVD was 26% and 37% (adjusted HR 3.01 [95% CI 1.38\u20136.58] and 2.52 [95% CI 1.55\u20134.10], respectively). The 10-year risk was 2% in those without CBP or CFBP and 26% in those with two CFBP only.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The presence of a &lt; 3-mm CBP may be associated with a significant ASCVD risk, especially if bilateral. This risk is better defined by the additional presence or absence of two CFBPs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1358863x251358270","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T06:45:03Z","timestamp":1758696303000},"page":"579-589","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Cardiovascular risk associated with carotid bifurcation plaques producing &lt; 50% stenosis and its modulation by presence of common femoral plaques: A cohort study"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3912-7394","authenticated-orcid":false,"given":"Andrew N","family":"Nicolaides","sequence":"first","affiliation":[{"name":"Vascular Screening and Diagnostic Centre, Nicosia, Cyprus"},{"name":"Department of Basic and Clinical Science, University of Nicosia Medical School, Nicosia, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrie G","family":"Panayiotou","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences, Cyprus University of Technology, Limassol, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura","family":"Griffin","sequence":"additional","affiliation":[{"name":"Vascular Screening and Diagnostic Centre, Nicosia, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodosis","family":"Tyllis","sequence":"additional","affiliation":[{"name":"Vascular Screening and Diagnostic Centre, Nicosia, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn","family":"Bond","sequence":"additional","affiliation":[{"name":"Vascular Screening and Diagnostic Centre, Nicosia, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niki","family":"Georgiou","sequence":"additional","affiliation":[{"name":"Vascular Screening and Diagnostic Centre, Nicosia, Cyprus"},{"name":"Donna Healthcare, Nicosia, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efthyvoulos","family":"Kyriacou","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering, Computer Engineering and Informatics, Cyprus University of Technology, Limassol, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costantinos","family":"Avraamides","sequence":"additional","affiliation":[{"name":"The Cyprus Institute of Cardiology, Nicosia, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Saba","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Cagliari, Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Critselis","sequence":"additional","affiliation":[{"name":"Department of Primary Care and Population Health, University of Nicosia Medical School, Nicosia, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiana","family":"Demetriou","sequence":"additional","affiliation":[{"name":"Department of Primary Care and Population Health, University of Nicosia Medical School, Nicosia, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Despo","family":"Ierodiakonou","sequence":"additional","affiliation":[{"name":"Department of Primary Care and Population Health, University of Nicosia Medical School, Nicosia, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Quattrocchi","sequence":"additional","affiliation":[{"name":"Department of Primary Care and Population Health, University of Nicosia Medical School, Nicosia, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Salameh","sequence":"additional","affiliation":[{"name":"Department of Primary Care and Population Health, University of Nicosia Medical School, Nicosia, 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