{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:16:00Z","timestamp":1777936560073,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vasc Med"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>\n                      Exercise transcutaneous oxygen pressure measurement (Exercise-TcPO\n                      <jats:sub>2<\/jats:sub>\n                      ) that has been validated with a constant-load treadmill protocol, is useful to assess patients with suspected lower-extremity peripheral artery disease (PAD). To date, nothing is known about its use with a graded protocol. The aim of this study is to compare the Exercise-TcPO\n                      <jats:sub>2<\/jats:sub>\n                      results obtained in patients with suspected PAD using a graded Gardner\u2013Skinner (3.2 km\/h, 2% grade increase every 2 min) versus a constant modified Strandness (3.2 km\/h, 10% grade) treadmill test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Patients with suspected PAD were assessed twice on the same day on a treadmill using the modified Strandness (Strand) followed by the Gardner\u2013Skinner (Gard) tests. In both tests, the decrease from resting oxygen pressure (DROP) indexes were measured at the buttock and calf levels as previously validated. A DROP\n                      <jats:sub>Strand<\/jats:sub>\n                      index \u2a7d \u221215 mmHg was considered positive for the diagnosis of PAD. The relationship between DROP\n                      <jats:sub>Gard<\/jats:sub>\n                      and DROP\n                      <jats:sub>Strand<\/jats:sub>\n                      as well as DROP value differences between the two tests and concordances were studied.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      This prospective study included 40 patients. Using a linear mixed model, the relationship between DROP\n                      <jats:sub>Gard<\/jats:sub>\n                      and DROP\n                      <jats:sub>Strand<\/jats:sub>\n                      was defined as DROP\n                      <jats:sub>Gard<\/jats:sub>\n                      = 0.647 \u00d7 DROP\n                      <jats:sub>Strand<\/jats:sub>\n                      \u2013 1.858. The mean difference between DROP\n                      <jats:sub>Gard<\/jats:sub>\n                      and DROP\n                      <jats:sub>Strand<\/jats:sub>\n                      was \u22124.3 \u00b1 7.3 mmHg. Positive and negative agreements were 78.0% and 86.3%, respectively. The kappa coefficient between DROP\n                      <jats:sub>Gard<\/jats:sub>\n                      and DROP\n                      <jats:sub>Strand<\/jats:sub>\n                      was 0.65 [0.54; 0.77].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Exercise-TcPO\n                      <jats:sub>2<\/jats:sub>\n                      results using the Gardner\u2013Skinner and modified Strandness treadmill tests were highly correlated. This study suggests the use of a DROP\n                      <jats:sub>Gard<\/jats:sub>\n                      value \u2a7d \u221212 mmHg to diagnose PAD when performing Exercise-TcPO\n                      <jats:sub>2<\/jats:sub>\n                      with a Gardner\u2013Skinner test. However, this cut-off value should be confirmed against an imaging gold standard.\n                      <jats:bold>ClinicalTrials.gov identifier: NCT03186391<\/jats:bold>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1358863x251379810","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T04:10:52Z","timestamp":1762402252000},"page":"676-682","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Relationship between exercise transcutaneous oxygen pressure measurements with constant and graded treadmill tests"],"prefix":"10.1177","volume":"30","author":[{"given":"Cindy","family":"Vannier","sequence":"first","affiliation":[{"name":"Vascular Surgery Unit, University Hospital, Rennes, France"},{"name":"Vascular Medicine Unit, University Hospital, Rennes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ad\u00e9la\u00efde","family":"Gu\u00e9zais","sequence":"additional","affiliation":[{"name":"Vascular Medicine Unit, University Hospital, Rennes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjolaine","family":"Talbot","sequence":"additional","affiliation":[{"name":"Vascular Medicine Unit, University Hospital, Rennes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Le Faucheur","sequence":"additional","affiliation":[{"name":"University of Rennes, M2S (Laboratoire Mouvement, Sport, Sant\u00e9), Rennes, France"},{"name":"University of Rennes, INSERM CIC 1414, Rennes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1318-4745","authenticated-orcid":false,"given":"Guillaume","family":"Mah\u00e9","sequence":"additional","affiliation":[{"name":"Vascular Medicine Unit, University Hospital, Rennes, France"},{"name":"University of Rennes, M2S (Laboratoire Mouvement, Sport, Sant\u00e9), Rennes, France"},{"name":"University of Rennes, INSERM CIC 1414, Rennes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,11,5]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(19)30255-4"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae179"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2023.08.067"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1024\/0301-1526\/a000638"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2020.11.011"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0219082"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.759666"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000060500.60646.E0"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2015.00033"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-019-02340-w"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-020-02360-x"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004522"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-16-1316"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/cpf.12626"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199104000-00003"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/000331979704800305"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e318276fbcb"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2015.09.005"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2009.01.042"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X14567030"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2018.08.025"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2832"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f2125"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90837-8"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v082.i13"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-24277-4"},{"key":"e_1_3_3_30_2","first-page":"80","article-title":"Transcutaneous oxygen pressure measurements (tcpO2) at ankle during exercise in arterial claudication","volume":"24","author":"Abraham P","year":"2005","unstructured":"Abraham P, Picquet J, Bouy\u00e9 P, et al. 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