{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T10:19:18Z","timestamp":1789553958262,"version":"build-2803163510"},"reference-count":21,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/15004-0"],"award-info":[{"award-number":["2016\/15004-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vasc Med"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Sclerotherapy is the treatment of choice for telangiectasias and reticular veins of the lower limbs, but long-term follow-up raises concerns about recurrence. This study aimed to evaluate the long-term outcomes of sclerotherapy for lower-limb telangiectasias and reticular veins over 3 years, focusing on disease control, pigmentation, and matting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A prospective, blinded cohort study followed patients treated with a single sclerotherapy session for telangiectasias (Study 1) or reticular veins (Study 2). Two groups were compae2-1358red: Group 1 received 0.2% polidocanol in 70% hypertonic glucose (PDHG) and Group 2 received 75% hypertonic glucose (HG) alone. Data were collected at 60 days and 3 years posttreatment. Analyses included recurrence, pigmentation, and matting. Photographic measurements were performed using ImageJ\u2122 software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 43 patients were included in Study 1 and 35 in Study 2, with a mean follow-up of 36 months in both. The groups were epidemiologically similar. Recurrence occurred in both studies. In Study 1, almost all the patients had recurrence of telangiectasias, with no significant difference between treatments. In Study 2, recurrence was minimal and favored PDHG (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.016). Pigmentation resolved mainly over time, with no significant intergroup or interstudy differences. Matting was more persistent in telangiectasias but nearly disappeared in reticular veins, with no significant group differences.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Telangiectasia recurrence was common after 3 years, regardless of treatment. In contrast, reticular veins showed minimal recurrence, particularly with PDHG. Pigmentation generally resolved spontaneously. Matting was more persistent in telangiectasias than in reticular veins. These findings support the long-term viability of both approaches in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1358863x251412739","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T06:15:25Z","timestamp":1774332925000},"page":"349-359","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Long-term follow-up of sclerotherapy of telangiectasias and reticular veins in lower limbs: Glucose versus polidocanol diluted in glucose"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6851-2841","authenticated-orcid":false,"given":"Matheus","family":"Bertanha","sequence":"first","affiliation":[{"name":"Department of Surgery and Orthopedics, School of Medicine, Botucatu, S\u00e3o Paulo State University (UNESP), Botucatu, SP, Brazil"},{"name":"Applied Biotechnology Laboratory, Research Nucleus of Clinical Hospital of School of Medicine, Botucatu, SP, Brazil"},{"name":"Clinical Hospital of School of Medicine, Botucatu, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9091-0224","authenticated-orcid":false,"given":"Vinicius Tadeu Ramos da Silva","family":"Grillo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Medical School, S\u00e3o Lucas University Center, Porto Velho, RO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caio Paiva","family":"Pellizzer","sequence":"additional","affiliation":[{"name":"Department of Surgery and Orthopedics, School of Medicine, Botucatu, S\u00e3o Paulo State University (UNESP), Botucatu, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7972-8472","authenticated-orcid":false,"given":"Lenize da Silva","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Surgery and Orthopedics, School of Medicine, Botucatu, S\u00e3o Paulo State University (UNESP), Botucatu, SP, Brazil"},{"name":"Applied Biotechnology Laboratory, Research Nucleus of Clinical Hospital of School of Medicine, Botucatu, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9679-7207","authenticated-orcid":false,"given":"Pedro Luciano","family":"Mellucci Filho","sequence":"additional","affiliation":[{"name":"Department of Surgery and Orthopedics, School of Medicine, Botucatu, S\u00e3o Paulo State University (UNESP), Botucatu, SP, Brazil"},{"name":"Clinical Hospital of School of Medicine, Botucatu, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8753-646X","authenticated-orcid":false,"given":"Pedro Luiz Toledo de Arruda","family":"Louren\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Surgery and Orthopedics, School of Medicine, Botucatu, S\u00e3o Paulo State University (UNESP), Botucatu, SP, Brazil"},{"name":"Clinical Hospital of School of Medicine, Botucatu, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2271-5878","authenticated-orcid":false,"given":"Marcone Lima","family":"Sobreira","sequence":"additional","affiliation":[{"name":"Department of Surgery and Orthopedics, School of Medicine, Botucatu, S\u00e3o Paulo State University (UNESP), Botucatu, SP, Brazil"},{"name":"Clinical Hospital of School of Medicine, Botucatu, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2015.02.014"},{"key":"e_1_3_2_3_2","article-title":"Treatment for telangiectasias and reticular veins","volume":"10","author":"Nakano LC","year":"2021","unstructured":"Nakano LC, Cacione DG, Baptista-Silva JC, Flumignan RL. Treatment for telangiectasias and reticular veins. Cochrane Database Syst Rev 2021; 10: CD012723.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2019.12.075"},{"key":"e_1_3_2_5_2","article-title":"Effectiveness of sclerotherapy to cure lower limb chronic venous insufficiency Grades 1\u20136: A systematic review and meta-analysis","volume":"15","author":"Dewi DAR","year":"2023","unstructured":"Dewi DAR, Arimuko A, Norawati L, et al. Effectiveness of sclerotherapy to cure lower limb chronic venous insufficiency Grades 1\u20136: A systematic review and meta-analysis. Cureus 2023; 15: e49770.","journal-title":"Cureus"},{"key":"e_1_3_2_6_2","article-title":"[Classification and mechanism of action of sclerosing agents] [Article in French]","volume":"22","author":"Imhoff E","year":"1969","unstructured":"Imhoff E, Stemmer R. [Classification and mechanism of action of sclerosing agents] [Article in French]. 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Sclerotherapy e-book, 6th edition: Treatment of varicose and telangiectatic leg veins (expert consult). Elsevier, 2016."},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/026835559601100209"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1987.tb00940.x"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/0268355517736178"},{"key":"e_1_3_2_22_2","first-page":"130","article-title":"How to manage complications after sclerotherapy","volume":"24","author":"Reina L.","year":"2017","unstructured":"Reina L. How to manage complications after sclerotherapy. 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