{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T08:32:04Z","timestamp":1786609924599,"version":"build-2736575974"},"reference-count":26,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP 23K15097"],"award-info":[{"award-number":["JP 23K15097"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vasc Med"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The impact of lipid-rich plaques (LRPs) in the femoropopliteal artery on limb outcomes remains underexplored. We investigated the influence of LRPs on limb outcomes in patients undergoing endovascular therapy (EVT) for femoropopliteal disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This single-center, prospective noninterventional observational study included patients undergoing drug-coated balloon angioplasty for femoropopliteal disease between July 2022 and November 2024. Near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) assessment was conducted on the entire femoropopliteal arterial segment. LRP was defined as plaque with a maximum lipid-core burden index in any 4-mm region &gt; 400. The primary outcome was major adverse limb events (MALEs) at 12 months. Secondary outcomes included primary patency and target-vessel revascularization (TVR) at 12 months. TVR was defined as any repeat EVT or surgical bypass of any segment of the target vessel.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Fifty participants were divided into LRP (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 19) and non-LRP (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 31) groups. The LRP group had significantly lower freedom from MALE at 12 months compared with the non-LRP group (69.1%, 95% CI: 35.7\u201387.6 vs 92.3%, 95% CI: 72.1\u201398.0, log-rank\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.01). LRP was associated with poorer freedom from MALE at 12 months (hazard ratio [HR]: 6.3, 95% CI: 1.3\u201338.8,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.02). Both groups showed comparable primary patency and freedom from TVR at 12 months (log-rank\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.03 for both). LRP was associated with lower primary patency (HR: 5.1, 95% CI: 0.97\u201326.7,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.054) and lower freedom from TVR (HR: 5.3, 95% CI: 1.01\u201327.8,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.049) at 12 months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      LRPs were associated with poor 12-month limb outcomes in patients undergoing EVT for femoropopliteal disease.\n                      <jats:bold>University Hospital Medical Information Network (UMIN) Clinical Trials Registry ID:<\/jats:bold>\n                      <jats:bold>UMIN000049231<\/jats:bold>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1358863x261425583","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T12:22:51Z","timestamp":1774959771000},"page":"505-516","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of lipid-rich plaques in the femoropopliteal artery on limb outcomes in patients undergoing endovascular therapy"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2897-4766","authenticated-orcid":false,"given":"Yusuke","family":"Sato","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuji","family":"Morishita","sequence":"additional","affiliation":[{"name":"Internal Medicine, Matsunami General Hospital, Gifu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuhiro","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Tama","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanae","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Ishida","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyasu","family":"Uzui","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Tada","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"e_1_3_3_2_2","article-title":"Global burden of peripheral artery disease and its risk factors, 1990\u20132019: A systematic analysis for the Global Burden of Disease Study 2019","volume":"11","author":"GBD 2019 Peripheral Artery Disease Collaborators","year":"2023","unstructured":"GBD 2019 Peripheral Artery Disease Collaborators. 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