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Noninvasive vascular assessments were performed within an ancillary study (2012\u20132017). Tests included carotid\u2013femoral pulse wave velocity, carotid\u2013brachial pulse wave velocity, carotid\u2013radial pulse wave velocity, central pulse pressure, forward pressure wave, and characteristic impedance, as well as brachial artery baseline and hyperemic flow velocities. Linear regression models, adjusted for age, age squared, sex, and heart rate, assessed the associations of LE8 composite and component scores with vascular function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A higher LE8 score was associated with lower carotid\u2013femoral pulse wave velocity (\u03b2 = \u22120.32; 95% CI: \u20130.42, \u20130.21;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.0001), characteristic impedance (\u03b2 = \u22120.57; 95% CI: \u20130.93, \u20130.20;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.0024), forward pressure wave amplitude (\u03b2 = \u22120.21; 95% CI: \u20130.26, \u20130.16;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.0001), central pulse pressure (\u03b2 = \u22120.25; 95% CI: \u20130.32, \u20130.19;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.0001), and brachial baseline flow velocity (\u03b2 = \u22120.013; 95% CI: \u20130.023, \u20130.002;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.021). Higher LE8 scores were associated with higher brachial hyperemic flow velocity (\u03b2 = 0.095; 95% CI: 0.035, 0.15;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.0018). Blood glucose and blood pressure were the components most significantly associated with vascular function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our findings support the concept that a healthy lifestyle is predictive of better vascular function. Future longitudinal studies are warranted to investigate whether improving LE8 scores leads to improved vascular function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1358863x261444663","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:53:36Z","timestamp":1782230016000},"page":"463-473","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Relations of Life\u2019s Essential 8 score with arterial and microvascular function: The Jackson Heart Study"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2764-2716","authenticated-orcid":false,"given":"Arko S","family":"Dhar","sequence":"first","affiliation":[{"name":"University of Mississippi Medical Center, Jackson, MS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William B","family":"Hillegass","sequence":"additional","affiliation":[{"name":"University of Mississippi Medical Center, Jackson, MS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leroy L","family":"Cooper","sequence":"additional","affiliation":[{"name":"Vassar College, Poughkeepsie, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abu Yusuf","family":"Ansari","sequence":"additional","affiliation":[{"name":"Jackson Heart Study, Coordinating Center, Jackson, MS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramachandran S","family":"Vasan","sequence":"additional","affiliation":[{"name":"University of Texas School of Public Health, San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Cardiovascular Engineering, Inc., Needham, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ervin R","family":"Fox","sequence":"additional","affiliation":[{"name":"University of Mississippi Medical Center, Jackson, MS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6735a3"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32008-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192703"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.13131"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001078"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20043084"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.123.010568"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpc.2025.101083"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.769589"},{"key":"e_1_3_3_11_2","first-page":"35","article-title":"Effect of race and socioeconomic status on cardiovascular risk factor burden: The Cooper Center Longitudinal Study","volume":"23","author":"Frierson GM","year":"2013","unstructured":"Frierson GM, Howard EN, DeFina LE, et al. 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