{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:49:02Z","timestamp":1791953342838,"version":"4.3.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000050","name":"national heart, lung, and blood institute","doi-asserted-by":"publisher","award":["HL158801-01"],"award-info":[{"award-number":["HL158801-01"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vasc Med"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Thoracic aortic thrombosis (TAT) is a rare, but important cause of arterial thromboembolism (ATE). There is a paucity of published data on TAT; therefore, risk stratification and management are challenging. In this study, we evaluated risk factors, presentation, and outcomes of patients diagnosed with TAT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this retrospective analysis, we analyzed data on all patients diagnosed with TAT by computed tomographic angiography between 2013 and 2024 at a single tertiary care center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 149 patients with an average age of 69.6 years (IQR 60.1\u201377.1) and 45.0% men were included. The most proximal thrombus location was the ascending aorta, arch, and descending aorta in 20.8%, 19.5%, and 59.7% of patients, respectively. Thrombus was attributed to atherosclerosis in 28.2% of patients, aneurysm in 32.9%, and other\/unknown etiologies for the remainder of the cohort. Approximately 25% of patients presented with ATE. In a multivariable analysis, risk factors associated with ATE included age &lt; 65 years (OR 7.9,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.01), arch involvement (OR 3.7,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.04), thrombus associated with atherosclerosis (OR 11.2,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.042), and thrombus in nonaneurysmal\/nonatherosclerotic aortas (OR 32.1,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.01) in patients with CT-detected aortic thrombus. Patients with aneurysmal or atherosclerotic etiologies were less likely to be managed with anticoagulation (16% vs 61%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.01) and less likely to show thrombus regression or resolution (20% vs 68%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.01). Recurrent spontaneous embolic events occurred in three of 149 patients (median follow-up of 763 days; IQR 364\u20131559).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>A significant proportion of patients with thoracic aortic thrombus present with ATE. Younger patients with arch thrombosis from nonaneurysmal\/nonatherosclerotic etiologies are at the highest risk of ATE. Patients with nonaneurysmal\/nonatherosclerotic etiologies of aortic thrombus were more likely to be treated with anticoagulation and show thrombus regression\/resolution; however, the rate of recurrent spontaneous embolic events was low.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1358863x261445934","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:21:36Z","timestamp":1790266896000},"page":"685-695","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical characteristics, presentation, and outcomes in patients with thoracic aortic thrombus"],"prefix":"10.1177","volume":"31","author":[{"given":"Rohitha","family":"Moudgal","sequence":"first","affiliation":[{"name":"Robert and Suzanne Tomsich Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahad","family":"Alkhalfan","sequence":"additional","affiliation":[{"name":"Robert and Suzanne Tomsich Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judah","family":"Rajendran","sequence":"additional","affiliation":[{"name":"Robert and Suzanne Tomsich Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric E","family":"Roselli","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis J","family":"Caputo","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venu","family":"Menon","sequence":"additional","affiliation":[{"name":"Robert and Suzanne Tomsich Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9640-6774","authenticated-orcid":false,"given":"Leben","family":"Tefera","sequence":"additional","affiliation":[{"name":"Robert and Suzanne Tomsich Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen E","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A","family":"Bolen","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milind Y","family":"Desai","sequence":"additional","affiliation":[{"name":"Robert and Suzanne Tomsich Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidyasagar","family":"Kalahasti","sequence":"additional","affiliation":[{"name":"Robert and Suzanne Tomsich Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9616-1540","authenticated-orcid":false,"given":"Scott J","family":"Cameron","sequence":"additional","affiliation":[{"name":"Robert and Suzanne Tomsich Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8210-8394","authenticated-orcid":false,"given":"Pulkit","family":"Chaudhury","sequence":"additional","affiliation":[{"name":"Robert and Suzanne Tomsich Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, 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