{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:49:00Z","timestamp":1791953340250,"version":"4.3.4"},"reference-count":81,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01-HC-25195, HHSN268201500001l, and 75N92019D0003"],"award-info":[{"award-number":["N01-HC-25195, HHSN268201500001l, and 75N92019D0003"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"national heart, lung, and blood institute","doi-asserted-by":"publisher","award":["HL70100, HL092577, 2U54HL120163, AG066010, R01HL092577, R01HL155717,"],"award-info":[{"award-number":["HL70100, HL092577, 2U54HL120163, AG066010, R01HL092577, R01HL155717,"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vasc Med"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Central arterial stiffness and pressure pulsatility are key measures of arterial health and cardiovascular disease (CVD). Acute physical activity (PA) improves vascular function; however, its relationship with arterial health across varying habitual PA levels remains understudied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We analyzed Framingham Heart Study (FHS) data (Generation 2: Exam 8, 2005\u20132008,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 2999 and Generation 3: Exam 1, 2002\u20132005,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 4064). Habitual PA was assessed using a standardized questionnaire. Carotid-femoral pulse wave velocity (niCFPWV, inverse-transformed CFPWV), central pulse pressure (CPP), and forward wave pressure (FWP) were measured using applanation tonometry. We examined associations between PA scores (as quintiles) and arterial health using linear regression and effect modification by age and sex, as well as mediation by arterial health measures on heart failure, CVD mortality, and all-cause mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In 6451 FHS participants (mean age 50 \u00b1 15 years, 55% women), the highest quintile of PA was associated with lower aortic stiffness (niCFPWV, \u03b2 = \u22120.06 \u00b1 0.02,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.01). Continuous PA was associated with higher CPP (std \u03b2 = 0.02 \u00b1 0.01,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.03) but not FWP. We observed an age-interaction: PA was associated with lower niCFPWV in individuals \u2a7e 48 years (std \u03b2 = \u22120.21 \u00b1 0.07,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.005) and higher CPP in those &lt; 48 years (std \u03b2 = 0.01 \u00b1 0.004,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.01). No significant effect modification by sex was noted. In stratified analyses, PA was associated with higher CPP among individuals without hypertension (\u03b2 = 0.02 \u00b1 0.01,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.02), but not among those with hypertension. In mediation analyses, vascular measures did not contribute significantly to cardiovascular outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Higher PA score was associated with lower arterial stiffness, particularly in older adults, and with higher pressure pulsatility in younger adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1358863x261447862","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T12:19:35Z","timestamp":1788178775000},"page":"629-638","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of physical activity with arterial stiffness and pulsatility in a community-based cohort"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8450-0349","authenticated-orcid":false,"given":"Mawra","family":"Jha","sequence":"first","affiliation":[{"name":"Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Meagher","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole L","family":"Spartano","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Diabetes, Nutrition, and Weight Management, Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emelia J","family":"Benjamin","sequence":"additional","affiliation":[{"name":"Boston University\u2019s and NHLBI\u2019s Framingham Heart Study, Framingham, MA, USA"},{"name":"Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA"},{"name":"Section of Cardiovascular Medicine, Department of Medicine, Boston Medical Center, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramachandran S","family":"Vasan","sequence":"additional","affiliation":[{"name":"University of Texas School of Public Health, San Antonio, TX, USA"},{"name":"Departments of Medicine and Population Health Sciences, University of Texas Health Science Center, San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary F","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Cardiovascular Engineering Inc., Needham, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie W","family":"Tsao","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.14515"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.886655"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.318061"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02346-0"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.115.004426"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacadv.2023.100409"},{"key":"e_1_3_2_8_2","article-title":"Association of estimated pulse wave velocity with cardiovascular disease outcomes and all-cause death: A systematic review and meta-analysis","volume":"12","author":"Li J","year":"2025","unstructured":"Li J, Jiang C, Ma J, et al. 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