{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:49:00Z","timestamp":1791953340257,"version":"4.3.4"},"reference-count":55,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Ningxia Natural Science Foundation","award":["2025AAC030898"],"award-info":[{"award-number":["2025AAC030898"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vasc Med"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Peripheral artery disease (PAD) is a prevalent manifestation of systemic atherosclerosis and is associated with substantial morbidity, impaired functional capacity, and adverse cardiovascular outcomes. Although reduced walking performance is a defining clinical feature of PAD, the underlying biological responses to acute physiological stress remain poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a prospective observational study including 35 patients with PAD and 36 control participants. All participants\u2019 serum samples were collected immediately before exercise and 5 minutes after exercise. Acute metabolic responses were quantified using targeted liquid chromatography-tandem mass spectrometry. Functional assessments, between-group comparisons, and associations with disease severity were evaluated using nonparametric methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Compared with control participants, patients with PAD exhibited distinct alterations in exercise-induced metabolic responses. Hypoxanthine showed a robust postexercise increase in controls but a blunted and directionally opposite response in PAD (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001), whereas 2-oxoglutarate increased significantly following exercise in PAD but not in controls (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001). In exploratory analyses within the PAD group, exercise-induced changes in hypoxanthine and 2-oxoglutarate were not significantly correlated with ankle-brachial index (ABI) or 6-minute walk distance (6MWD) in the available cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>PAD is associated with impaired metabolic flexibility during acute exercise, characterized by altered purine- and tricarboxylic acid-related metabolic responses to exercise, supporting the concept that acute metabolic responses provide clinically relevant information beyond resting assessments in PAD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1358863x261452546","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:39:45Z","timestamp":1787837985000},"page":"663-674","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Impaired acute metabolic responses to submaximal exercise in peripheral artery disease (PAD)"],"prefix":"10.1177","volume":"31","author":[{"given":"Lei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, General Hospital of Ningxia Medical University, Yinchuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhu","sequence":"additional","affiliation":[{"name":"Medical Laboratory, Hospital of Cardiovascular and Cerebrovascular Diseases, General Hospital of Ningxia Medical University, Yinchuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongping","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Medicine, Yecheng County People\u2019s Hospital, Kashgar Prefecture, Xinjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Molecular Target &amp; Clinical Pharmacology, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China"},{"name":"Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2676-6982","authenticated-orcid":false,"given":"Jin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Laser, General Hospital of Ningxia Medical University, Yinchuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(25)00509-4"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-025-00651-0"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc25-1082"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.03.008"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.124.22832"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2012.tb00473.x"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.3391"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.34590"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.2126"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11123131"},{"key":"e_1_3_4_12_2","article-title":"Circadian dysfunction in the skeletal muscle impairs limb perfusion and muscle regeneration in peripheral artery disease","volume":"45","author":"Zhu P","year":"2025","unstructured":"Zhu P, Chao CL, Steffeck AWT, et al. Circadian dysfunction in the skeletal muscle impairs limb perfusion and muscle regeneration in peripheral artery disease. Arterioscler Thromb Vasc Biol 2025; 45: e30\u2013e47.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.123.323161"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2025.1606769"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpet.2025.103607"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00045.2024"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103371"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000003608"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.12.008"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-024-00786-4"},{"key":"e_1_3_4_21_2","first-page":"828","article-title":"Drought stress responses in Arabica coffee genotypes: Physiological and metabolic insights","volume":"13","author":"Chekol H","year":"2024","unstructured":"Chekol H, Warkineh B, Shimber T, et al. Drought stress responses in Arabica coffee genotypes: Physiological and metabolic insights. Plants (Basel) 2024; 13: 828.","journal-title":"Plants (Basel)"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclepro.2024.141653"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-77352-3"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1088\/2632-2153\/adf810"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2024.09.010"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1113\/JP286395"},{"key":"e_1_3_4_27_2","first-page":"69","article-title":"Biochemistry of exercise","volume":"24","author":"Rodrigues dos Santos JA","year":"2024","unstructured":"Rodrigues dos Santos JA, Concei\u00e7\u00e3o F. Biochemistry of exercise. Rev Port Cien Desporto 2024; 24: 69\u201389.","journal-title":"Rev Port Cien Desporto"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1123\/ijspp.2024-0397"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1982.tb01945.x"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(80)90067-0"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1177\/000331979204300206"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2009.10.015"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ24-0358"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.4c03719"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2025.03.005"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.3390\/biology14081069"},{"key":"e_1_3_4_37_2","first-page":"243","article-title":"Dietary nitrate supplementation very slightly mitigates the oxidative stress induced by high-intensity training performed in normobaric hypoxia","volume":"42","author":"Sousa A","year":"2025","unstructured":"Sousa A, Chambion-Diaz M, Pialoux V, et al. Dietary nitrate supplementation very slightly mitigates the oxidative stress induced by high-intensity training performed in normobaric hypoxia. Biol Sport 2025; 42: 243\u2013251.","journal-title":"Biol Sport"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu16142341"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/cts.13740"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2024.tb00292.x"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs0640333"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(92)90069-M"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/136.1.98"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2025.108307"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2024-0054"},{"key":"e_1_3_4_46_2","first-page":"552","article-title":"2-Oxoglutarate: Linking TCA cycle function with amino acid, glucosinolate, flavonoid, alkaloid, and gibberellin biosynthesis","volume":"5","author":"Ara\u00fajo WL","year":"2014","unstructured":"Ara\u00fajo WL, Martins AO, Fernie AR, Tohge T. 2-Oxoglutarate: Linking TCA cycle function with amino acid, glucosinolate, flavonoid, alkaloid, and gibberellin biosynthesis. Front Plant Sci 2014; 5: 552.","journal-title":"Front Plant Sci"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu17213336"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afae114"},{"key":"e_1_3_4_49_2","first-page":"523","article-title":"Mitochondrial fatty acid beta-oxidation: A possible therapeutic target for skeletal muscle lipotoxicity in peripheral artery disease myopathy","volume":"23","author":"Bradley CE","year":"2024","unstructured":"Bradley CE, Fletcher E, Wilkinson T, et al. Mitochondrial fatty acid beta-oxidation: A possible therapeutic target for skeletal muscle lipotoxicity in peripheral artery disease myopathy. EXCLI J 2024; 23: 523\u2013533.","journal-title":"EXCLI J"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9121304"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2024.167584"},{"key":"e_1_3_4_52_2","first-page":"1208","article-title":"Ultrastructural alterations and mitochondrial dysfunction in skeletal muscle of peripheral artery disease patients: Implications for early therapeutic interventions","volume":"23","author":"Wilburn D","year":"2024","unstructured":"Wilburn D, Fletcher E, Papoutsi E, et al. Ultrastructural alterations and mitochondrial dysfunction in skeletal muscle of peripheral artery disease patients: Implications for early therapeutic interventions. EXCLI J 2024; 23: 1208\u20131225.","journal-title":"EXCLI J"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.318242"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11030758"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.313831"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvn.2023.11.003"}],"container-title":["Vascular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1358863X261452546","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1358863X261452546","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1358863X261452546","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:21:13Z","timestamp":1791951673000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1358863X261452546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,27]]},"references-count":55,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1177\/1358863X261452546"],"URL":"https:\/\/doi.org\/10.1177\/1358863x261452546","relation":{},"ISSN":["1358-863X","1477-0377"],"issn-type":[{"value":"1358-863X","type":"print"},{"value":"1477-0377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,27]]}}}