{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:49:00Z","timestamp":1791953340236,"version":"4.3.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Else Jebsen Foundation"},{"name":"Wessel- and Friedrich Bluhme Foundation"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vasc Med"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>E-cigarette use is increasing significantly worldwide, particularly among young people. However, the cardiovascular impact of nicotine exposure during adolescence remains unclear. Although cigarette and e-cigarette use are known to increase arterial stiffness in adults, data from younger populations are lacking. Early vascular alterations may indicate a premature cardiovascular risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In a cross-sectional study, we assessed arterial stiffness and central hemodynamics using the Mobil-O-Graph device (IEM GmbH). Smoking and vaping behaviors were evaluated using standardized questionnaires. The participants were classified according to the frequency and combination of cigarette and e-cigarette use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      From 444 involved school-aged adolescents (median age: 15.0 years), 5.0% reported e-cigarette consumption and 4.5% dual use. The adolescents reporting dual use of cigarettes and e-cigarettes exhibited significantly higher peripheral diastolic blood pressure than those with infrequent (&lt; 1 per week) or no nicotine use (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.003). Central diastolic blood pressure was also elevated in the dual users (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.007).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Dual exposure to combustible and electronic nicotine products was associated with higher diastolic blood pressure among adolescents in this cohort. These findings suggest that nicotine-induced vascular changes may occur earlier in life than previously recognized. Preventive interventions targeting youth are needed to mitigate long-term cardiovascular risks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1358863x261462859","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:39:26Z","timestamp":1790267966000},"page":"651-659","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Dual use of cigarettes and e-cigarettes is associated with higher diastolic blood pressure in adolescents: The School*Vape*Science study"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7830-4256","authenticated-orcid":false,"given":"Mareike","family":"L\u00fcthgen","sequence":"first","affiliation":[{"name":"Medical Clinic III (Pulmonology), University Hospital Schleswig-Holstein, L\u00fcbeck, Germany"},{"name":"Airway Research Center North, Member of the German Center for Lung Research (DZL), Gro\u00dfhansdorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Burgard","sequence":"additional","affiliation":[{"name":"Medical Clinic III (Pulmonology), University Hospital Schleswig-Holstein, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maike","family":"Truempelmann","sequence":"additional","affiliation":[{"name":"Medical Clinic III (Pulmonology), University Hospital Schleswig-Holstein, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Axt","sequence":"additional","affiliation":[{"name":"Medical Clinic III (Pulmonology), University Hospital Schleswig-Holstein, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrike A","family":"Faesser","sequence":"additional","affiliation":[{"name":"Medical Clinic III (Pulmonology), University Hospital Schleswig-Holstein, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4811-9704","authenticated-orcid":false,"given":"Tobias","family":"Jagomast","sequence":"additional","affiliation":[{"name":"Medical Clinic III (Pulmonology), University Hospital Schleswig-Holstein, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Dr\u00f6mann","sequence":"additional","affiliation":[{"name":"Medical Clinic III (Pulmonology), University Hospital Schleswig-Holstein, L\u00fcbeck, Germany"},{"name":"Airway Research Center North, Member of the German Center for Lung Research (DZL), Gro\u00dfhansdorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Folke","family":"Brinkmann","sequence":"additional","affiliation":[{"name":"Airway Research Center North, Member of the German Center for Lung Research (DZL), Gro\u00dfhansdorf, Germany"},{"name":"Department of Pediatrics, University Hospital Schleswig-Holstein, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loana","family":"Penner","sequence":"additional","affiliation":[{"name":"Airway Research Center North, Member of the German Center for Lung Research (DZL), Gro\u00dfhansdorf, Germany"},{"name":"Department of Pediatrics, University Hospital Schleswig-Holstein, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaas F","family":"Franzen","sequence":"additional","affiliation":[{"name":"Medical Clinic III (Pulmonology), University Hospital Schleswig-Holstein, L\u00fcbeck, Germany"},{"name":"Airway Research Center North, Member of the German Center for Lung Research (DZL), Gro\u00dfhansdorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"e_1_3_4_2_2","first-page":"1001","article-title":"Use of tobacco cigarettes, e-cigarettes, and shishas among children and adolescents: Results of the \u2018Pr\u00e4ventionsradar\u2019 from 2016 to 2023","volume":"77","author":"Hanewinkel R","year":"2023","unstructured":"Hanewinkel R, Hansen J. Use of tobacco cigarettes, e-cigarettes, and shishas among children and adolescents: Results of the \u2018Pr\u00e4ventionsradar\u2019 from 2016 to 2023. Pneumologie 2023; 77: 1001\u20131008.","journal-title":"Pneumologie"},{"key":"e_1_3_4_3_2","unstructured":"Charrier L van Dorsselaer S Canale N et al. A focus on adolescent substance use in Europe central Asia and Canada. Health Behaviour in School-aged Children international report from the 2021\/2022 survey. Volume 3. World Health Organization https:\/\/www.who.int\/europe\/publications\/i\/item\/9789289060936 (2024 accessed October 26 2024)."},{"key":"e_1_3_4_4_2","unstructured":"McNeill A Brose LS Calder R et al. Evidence review of e\u2011cigarettes and heated tobacco products 2018. 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