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Existing research has primarily focused on structuring environments to be responsive to the needs experienced by children with FASD rather than improving their functioning. The purpose of this study is to present outcomes from an early psychosocial intervention with 10 adopted, maltreated young children diagnosed with FASD, aged 10\u201353\u2009months ( M\u2009=\u200935\u2009months), and their adoptive parents. The potential for early, targeted interventions to improve developmental outcomes for children with prenatal alcohol exposure was examined, as well as improving the skills of and reducing stress experienced by their adoptive parents. Based on the outcomes of a neurodevelopmentally informed assessment protocol, the 10 children whose data are presented were recommended to receive a range of regulatory, somatosensory, relational, and cognitive enrichments. As part of their treatment, children and caregivers received Child\u2013Parent Psychotherapy (CPP), and caregivers (here, adoptive parents) also received Mindful Parenting Education (MPE). Related-samples Wilcoxon signed-rank tests indicated that scores of several measures of child developmental functioning improved from pre- to post-intervention and that parents\u2019 caregiving skills improved while their caregiving stress decreased. Reliable change analyses indicated that change observed from pre- to post-intervention was reliable. The promise of using neurodevelopmentally informed assessment strategies to sequence interventions for young children with diverse neurodevelopmental insults is discussed.<\/jats:p>","DOI":"10.1177\/1359104516636438","type":"journal-article","created":{"date-parts":[[2016,3,16]],"date-time":"2016-03-16T21:34:02Z","timestamp":1458164042000},"page":"551-567","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":39,"title":["Clinical improvements in adopted children with fetal alcohol spectrum disorders through neurodevelopmentally informed clinical intervention: A pilot study"],"prefix":"10.1177","volume":"21","author":[{"given":"Zohreh","family":"Zarnegar","sequence":"first","affiliation":[{"name":"Los Angeles County Department of Mental Health, USA"},{"name":"Children\u2019s Health International, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin P","family":"Hambrick","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce D","family":"Perry","sequence":"additional","affiliation":[{"name":"The ChildTrauma Academy, USA"},{"name":"Northwestern University, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley P","family":"Azen","sequence":"additional","affiliation":[{"name":"University of Southern California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandra","family":"Peterson","sequence":"additional","affiliation":[{"name":"Telecare Corporation, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,7,26]]},"reference":[{"key":"bibr1-1359104516636438","volume-title":"Parenting Stress Index-Manual","author":"Abidin R. 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