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Children with DS and ASD, between 3 and 12 years old, attended a dance program during 16 sessions\/lessons, lasting 60 min, twice a week, in suitable place. Functional Independence Measure (FIM), Childhood Autism Rating Scale SF-36 quality of life survey, and Knowledge, Attitude and Practice Inquiry (KAP Inquiry) were applied before and after dance classes. Eleven participants concluded the study. Functional independence changes were observed in relation to self-care, sphincter control, locomotion, and communication domains. Children\u2019 \u201cquality of life\u201d reported by parents showed changes in functional capacity, vitality, mental health, physical and social aspects, and general state of health domains. 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