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It is the first to our knowledge to explore the mediating effect of mental health on sexual behaviour with a focus on a fast-growing developing country. Data were obtained from the National Health and Morbidity Survey 2017 (n = 27,497). Structural equation modelling was utilized to examine depression and anxiety as mediators of the relationships between sexual behaviour and smoking, alcohol drinking and illicit drug use, controlling for sociodemographic factors. Results showed that adolescents who smoked, consumed alcohol, used illicit drugs, and had depression and anxiety were more likely to engage in sexual behaviour than others. Depression and anxiety partially mediated the relationships between sexual behaviour and smoking, and illicit drug use. The association between alcohol drinking and sexual behaviour was fully mediated by depression and anxiety. In conclusion, lifestyles may affect sexual behaviour through mediation of mental health. Therefore, policymakers should take mental health factors into consideration when designing adolescent sexual behaviour preventative interventions.<\/jats:p>","DOI":"10.1177\/13591045221142497","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T23:28:15Z","timestamp":1669418895000},"page":"1341-1357","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Lifestyles and Sexual Behaviour Among School-Going Adolescents: A Mediational Role of Mental Health"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6793-7055","authenticated-orcid":false,"given":"Yong Kang","family":"Cheah","sequence":"first","affiliation":[{"name":"School of Economics, Finance and Banking, College of Business, Universiti Utara Malaysia, Sintok, Kedah, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabilah Hanis","family":"Zainuddin","sequence":"additional","affiliation":[{"name":"Sector for Biostatistics and Data Repository, National Institutes of Health, Ministry of Health Malaysia, Shah Alam, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee Cheong","family":"Kee","sequence":"additional","affiliation":[{"name":"Sector for Biostatistics and Data Repository, National Institutes of Health, Ministry of Health Malaysia, Shah Alam, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuang Hock","family":"Lim","sequence":"additional","affiliation":[{"name":"Special Research Centre, Institute for Medical Research, Ministry of Health Malaysia, Jalan Pahang, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Azahadi","family":"Omar","sequence":"additional","affiliation":[{"name":"Sector for Biostatistics and Data Repository, National Institutes of Health, Ministry of Health Malaysia, Shah Alam, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Ling","family":"Cheong","sequence":"additional","affiliation":[{"name":"Special Research Centre, Institute for Medical Research, Ministry of Health Malaysia, Jalan Pahang, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,11,25]]},"reference":[{"key":"bibr1-13591045221142497","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2005.08.016"},{"key":"bibr2-13591045221142497","doi-asserted-by":"publisher","DOI":"10.1007\/s12529-011-9159-4"},{"key":"bibr3-13591045221142497","doi-asserted-by":"publisher","DOI":"10.1093\/inthealth\/ihz092"},{"key":"bibr4-13591045221142497","doi-asserted-by":"publisher","DOI":"10.1002\/cpp.2085"},{"key":"bibr5-13591045221142497","doi-asserted-by":"publisher","DOI":"10.25133\/JPSSv26n4.021"},{"key":"bibr6-13591045221142497","doi-asserted-by":"publisher","DOI":"10.1080\/17450128.2016.1218095"},{"key":"bibr7-13591045221142497","doi-asserted-by":"publisher","DOI":"10.1017\/ipm.2014.83"},{"key":"bibr8-13591045221142497","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedhc.2018.11.006"},{"key":"bibr9-13591045221142497","volume-title":"Global school-based student health survey 2012","author":"Institute for Public Health","year":"2012"},{"key":"bibr10-13591045221142497","volume-title":"National health and morbidity survey 2017: Adolescent health survey","author":"Institute for Public Health","year":"2017"},{"key":"bibr11-13591045221142497","doi-asserted-by":"publisher","DOI":"10.1080\/00224499.2010.509892"},{"key":"bibr12-13591045221142497","doi-asserted-by":"publisher","DOI":"10.1016\/0273-2297(92)90014-S"},{"key":"bibr13-13591045221142497","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-017-4389-2"},{"key":"bibr14-13591045221142497","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.18.2348"},{"key":"bibr15-13591045221142497","doi-asserted-by":"publisher","DOI":"10.1177\/1010539514544356"},{"key":"bibr16-13591045221142497","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2214.2003.00357.x"},{"key":"bibr17-13591045221142497","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-7358(99)00070-7"},{"issue":"6","key":"bibr18-13591045221142497","first-page":"476","volume":"47","author":"Lee L. 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