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Diseases assessed include rheumatoid arthritis, psoriatic arthritis, psoriasis, ankylosing spondylitis, Crohn\u2019s disease, and ulcerative colitis. A total of 42 studies were included following a systematic search in PubMed\/MEDLINE. The review adhered to PRISMA guidelines and was registered in PROSPERO (CRD42024518043). Results highlight a high prevalence of sexual dysfunction in IMID patients, significantly impairing quality of life. Assessments were primarily conducted using the Female Sexual Function Index (FSFI) and the International Index of Erectile Function (IIEF). Women, particularly those with rheumatoid arthritis and inflammatory bowel disease, exhibited higher vulnerability, with risk factors being disease severity, pain, depression, and anxiety. These findings underscore the necessity of a multidisciplinary and biopsychosocial approach involving rheumatologists, gastroenterologists, psychologists, and sexologists. 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