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The current study examines the relationship between recent trauma and problematic alcohol use, testing anxiety as a mediator and self-compassion as a moderator. A sample of 727 American Indian adults completed measures of recent traumatic experiences, anxiety, problematic alcohol use, and self-compassion. Results indicated that anxiety mediated the relationship between trauma and alcohol use, suggesting that individuals with greater recent trauma exposure engage in increased problematic drinking partly due to increased anxiety. Contrary to expectations, rather than buffering the impact of trauma on anxiety, self-compassion strengthened the trauma-anxiety link. The current findings highlight the complexity of self-compassion as a protective factor and suggest a context-dependent effect. 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