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Disease severity was assessed using the Expanded Disability Status Scale (EDSS). Participants completed validated questionnaires measuring anxiety, depression, alexithymia, psychological resilience, and stigma. Relative to controls, pwMS exhibited significantly higher levels of anxiety, depression, and alexithymia, with no significant differences in resilience. Hierarchical regression analyses identified depression and stigma as the strongest predictors of anxiety. Given the high correlation between depression and anxiety, a secondary analysis excluding depression revealed stigma and resilience as significant predictors. These results indicate that anxiety in pwMS is influenced by multiple psychological and social factors beyond depression. 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