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Among FDRs who were the primary caregivers, higher levels of depression or lower levels of optimism, and more frequent experience of gastrointestinal symptoms were significantly associated with a higher probability of participating in colonoscopy and gastroscopy. In contrast, the opposite patterns were observed for FDRs who were non-primary caregivers. To our best knowledge, this is the first study to examine the interplay of gastrointestinal symptoms, psychological functioning, and caregiver role among FDRs of CRC patients. Tailored health education, with an emphasis on individual emotional needs and the caregiving role, should be specifically designed for FDRs to facilitate cancer screening.\n                  <\/jats:p>","DOI":"10.1177\/13591053261423319","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T05:17:03Z","timestamp":1775798223000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The frequency of experiencing gastrointestinal symptoms and screening behavior among first-degree relatives of colorectal cancer patients in China: The moderating effect of psychological functioning and caregiving role"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9177-2835","authenticated-orcid":false,"given":"Rui","family":"Bao","sequence":"first","affiliation":[{"name":"Shanghai Jiao Tong University School of Medicine, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1293-9006","authenticated-orcid":false,"given":"Jinhuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University School of Medicine, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zewen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Friendship Hospital, Capital Medical University, China"},{"name":"National Clinical Research Center for Digestive Diseases, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0445-0144","authenticated-orcid":false,"given":"Saloni Rameshchandra.","family":"Shah","sequence":"additional","affiliation":[{"name":"Beijing Friendship Hospital, Capital Medical University, China"},{"name":"National Clinical Research Center for Digestive Diseases, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6671-1443","authenticated-orcid":false,"given":"Kenish Sirajbhai.","family":"Salewala","sequence":"additional","affiliation":[{"name":"Beijing Friendship Hospital, Capital Medical University, China"},{"name":"National Clinical Research Center for Digestive Diseases, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mansi Pankajbhai.","family":"Kevadiya","sequence":"additional","affiliation":[{"name":"Beijing Friendship Hospital, Capital Medical University, China"},{"name":"National Clinical Research Center for Digestive Diseases, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinfeng","family":"Hu","sequence":"additional","affiliation":[{"name":"Inner Mongolia People\u2019s Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing Friendship Hospital, Capital Medical University, China"},{"name":"National Clinical Research Center for Digestive Diseases, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao","family":"Chu","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University School of Medicine, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2648.2009.04981.x"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2017.11.010"},{"key":"e_1_3_3_4_1","volume-title":"Multiple regression: Testing and interpreting interactions","author":"Aiken LS","year":"1991","unstructured":"Aiken LS, West SG (1991) Multiple regression: Testing and interpreting interactions. 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