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This cross-sectional study of 215 psoriasis patients assessed psychological variables using the Euthymia Scale, Basic Psychological Need Satisfaction and Frustration Scale, Demoralization Scale-II, FACIT-F, Patient Health Questionnaire-4, and Physician Global Assessment. Lower anxiety and higher satisfaction with autonomy, relatedness, and competence were associated with greater euthymia. Fatigue was associated with autonomy frustration and depression. Lower relatedness satisfaction and higher Meaning and Purpose dimension of demoralization were linked to higher risk of disease severity. 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