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This study examined symptom interrelationships in 271 Saudi patients with chronic diseases recruited from multiple health centers in Jeddah and Riyadh. Participants completed the PHQ-9, GAD-7, and the Fear of Progression Questionnaire\u2013Short Form. Network analysis showed that nervousness\/anxiety, little interest or pleasure in doing things, and fear of being unable to pursue hobbies were the most central symptoms. The main bridge symptoms were restlessness, fear that something awful might happen, inability to control worry, and little interest or pleasure in doing things. Elevated depressive, anxiety, and fear of disease progression symptoms were reported by 55.7%, 56.8%, and 88.5% of participants, respectively. These findings identify potential symptom-level intervention targets.<\/jats:p>","DOI":"10.1177\/13591053261475628","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T06:58:21Z","timestamp":1786517901000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Central and bridge symptoms of anxiety, depression, and fear of disease progression in Saudi patients with chronic diseases: A network analysis"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0456-9889","authenticated-orcid":false,"given":"Mogeda El Sayed","family":"El Keshky","sequence":"first","affiliation":[{"name":"King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radeah Mohammed","family":"Hamididin","sequence":"additional","affiliation":[{"name":"King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"crossref","unstructured":"Alenzi EO Fatima W Amara A et al. 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