{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:15:03Z","timestamp":1791112503785,"version":"4.1.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2005,10,1]],"date-time":"2005-10-01T00:00:00Z","timestamp":1128124800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We assessed predictors of changes in systolic (SBP) and diastolic (DBP) blood pressure during follow-up and of the development of hypertension in HIV-infected individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>International cohort collaborative study (D:A:D) of established prospective cohorts of HIV-1-infected patients. Longitudinal analysis of changes in blood pressure (BP) was performed using mixed effects models in 17170 patients. Predictors of development of hypertension during follow-up (systolic BP \u2265140 and\/or diastolic BP \u226590 mmHg or initiation of antihypertensive treatment) were assessed using Cox models in 8 984 patients with a normal BP level at baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>73548 BP measurements with a median of 4 per patient (interquartile range [IQR]: 2\u20136) were recorded over a median follow-up of 2.3 years (IQR: 1.5\u20132.6). Risk factors significantly associated with a development of higher systolic BP and diastolic BP (differences \u22655 mmHg and P-values &lt;0.001) during follow-up were: older age, male sex, higher body mass index (BMI) and use of BP-lowering drugs. In patients with normal BP at baseline, 1186 developed hypertension for an incidence of 72.1 per 1000 person-years (95% confidence interval: 68.2\u201376.0). Factors associated with development of hypertension were: male sex, higher BMI, older age, higher BP at baseline, high total cholesterol and clinical lipodystrophy. Cumulative duration of exposure to nucleoside reverse transcriptase inhibitors ( P=0.75), protease inhibitors ( P=0.92) as well as type of antiretroviral treatment at baseline ( P=0.18) were not associated with a higher risk of hypertension. Cumulative duration of exposure to non-nucleoside reverse transcriptase inhibitors (NNRTIs) was significantly associated with lower risk of hypertension (hazard ratio=0.78 and 0.67 for those treated \u226410 months and &gt;10 months compared with no exposure; P=0.005).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Increased blood pressure in HIV-infected individuals is associated with established risk factors for hypertension. There was no evidence for an independent deleterious effect of any class of antiretroviral drugs on BP, although the use of NNRTIs was associated with a lower risk of development of hypertension.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/135965350501000706","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T11:55:21Z","timestamp":1649937321000},"page":"811-823","source":"Crossref","is-referenced-by-count":98,"title":["Predictors of Hypertension and Changes of Blood Pressure in HIV-Infected Patients"],"prefix":"10.1177","volume":"10","author":[{"given":"Rodolphe","family":"Thi\u00e9baut","sequence":"first","affiliation":[{"name":"INSERM E0338 & U593, ISPED, Universit\u00e9 Victor Segalen Bordeaux 2, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wafaa M","family":"El-Sadr","sequence":"additional","affiliation":[{"name":"Community Program for Clinical Research on AIDS (CPCRA), Columbia 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R.G., Thompson W.M.IV, Chu A., Hernandez F. & Shelton M.J. Indinavir, not Nelfinavir, Is Associated with Systemic Hypertension When Compared to No Protease Inhibitor Therapy.\n                      8th Conference on Retroviruses and Opportunistic Infections\n                      . February 11\u201315 2001, Chicago, USA. Abstract 658."},{"key":"bibr16-135965350501000706","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200104130-00021"},{"key":"bibr17-135965350501000706","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh393"},{"key":"bibr18-135965350501000706","unstructured":"Yao L.K., O'Riordan M., Lederman M.M., Valdez H., Gripshover B., Rodriguez B., Salata R. & McComsey G.A. Lack of significant changes in blood pressure of HIV+ subjects, even after long -term use of PI therapy.\n                      14th World AIDS Conference\n                      . July 7\u201312 2002, Barcelona, Spain. Abstract B10302."},{"key":"bibr19-135965350501000706","unstructured":"Gomez F., Cousinou M., Trouillhet I., Herran M., Escobar M., Fernandez F.J. & Orihuela F.M. Arterial hypertension in HIV patients on HAART.\n                      14th World AIDS Conference\n                      . July 7\u201312 2002, Barcelona, Spain. Abstract B10285."},{"key":"bibr20-135965350501000706","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200305230-00010"},{"key":"bibr21-135965350501000706","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200409030-00010"},{"key":"bibr22-135965350501000706","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780070131"},{"key":"bibr23-135965350501000706","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2003.08.009"},{"key":"bibr24-135965350501000706","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2486"},{"key":"bibr25-135965350501000706","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a117592"},{"key":"bibr26-135965350501000706","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199905070-00009"},{"key":"bibr27-135965350501000706","doi-asserted-by":"publisher","DOI":"10.1310\/F2V7-3R46-VX6J-241R"},{"key":"bibr28-135965350501000706","doi-asserted-by":"publisher","DOI":"10.1086\/381783"},{"key":"bibr29-135965350501000706","doi-asserted-by":"publisher","DOI":"10.1080\/078538902317338652"},{"key":"bibr30-135965350501000706","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000124480.32233.8A"},{"key":"bibr31-135965350501000706","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1293.2002.00117.x"},{"key":"bibr32-135965350501000706","volume-title":"The World Health Report 2002: Risk to Health 2002","author":"World Health Organization.","year":"2002"},{"key":"bibr33-135965350501000706","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90944-Z"},{"key":"bibr34-135965350501000706","doi-asserted-by":"publisher","DOI":"10.1086\/378131"},{"key":"bibr35-135965350501000706","doi-asserted-by":"publisher","DOI":"10.1097\/00126097-200110000-00006"},{"key":"bibr36-135965350501000706","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(01)02324-X"}],"container-title":["Antiviral Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/135965350501000706","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/135965350501000706","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:53:18Z","timestamp":1777380798000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/135965350501000706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2005,10]]}},"alternative-id":["10.1177\/135965350501000706"],"URL":"https:\/\/doi.org\/10.1177\/135965350501000706","relation":{},"ISSN":["1359-6535","2040-2058"],"issn-type":[{"value":"1359-6535","type":"print"},{"value":"2040-2058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,10]]}}}