{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:01:14Z","timestamp":1793048474449,"version":"4.5.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T00:00:00Z","timestamp":1646611200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>Tenofovir alafenamide fumarate is a lipophilic prodrug of tenofovir which is preferentially metabolized in lymphatic tissue resulting in high concentrations of tenofovir (TFV) and its active diphosphate metabolite inside the cells that replicate HIV. Due to its selectivity for these tissues, lower total doses of TAF can be administered relative to tenofovir disoproxil fumarate (TDF) which results in improved bone and renal biomarkers. Tenofovir alafenamide fumarate has become the \u201cbackbone\u201d of multiple combination products for the treatment of HIV, combined with emtricitabine for PreP and as a monotherapy for the treatment or HBV.<\/jats:p>","DOI":"10.1177\/13596535211067600","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T03:45:02Z","timestamp":1646624702000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Tenofovir alafenamide fumarate"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2933-9468","authenticated-orcid":false,"given":"William A","family":"Lee","sequence":"first","affiliation":[{"name":"San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew K","family":"Cheng","sequence":"additional","affiliation":[{"name":"Akero Therapeutics, South San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,3,7]]},"reference":[{"key":"bibr1-13596535211067600","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.2.332"},{"key":"bibr2-13596535211067600","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.5.1898-1906.2005"},{"key":"bibr3-13596535211067600","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.5.1270"},{"key":"bibr4-13596535211067600","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.3.716-723.2002"},{"key":"bibr5-13596535211067600","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000167155.44980.e8"},{"key":"bibr6-13596535211067600","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.3.612"},{"key":"bibr7-13596535211067600","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012108719462"},{"key":"bibr8-13596535211067600","first-page":"90","volume":"17","author":"Sax PE","year":"2007","journal-title":"AIDS Reader"},{"key":"bibr9-13596535211067600","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283112b8e"},{"key":"bibr10-13596535211067600","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2006.05.020"},{"key":"bibr11-13596535211067600","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.9.2380"},{"key":"bibr12-13596535211067600","first-page":"362","volume":"25","author":"Shaw JP","year":"1997","journal-title":"Drug Metab Dispos"},{"key":"bibr13-13596535211067600","doi-asserted-by":"publisher","DOI":"10.1177\/095632029300400204"},{"key":"bibr14-13596535211067600","doi-asserted-by":"publisher","DOI":"10.1021\/jm9803931"},{"key":"bibr15-13596535211067600","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00968-06"},{"key":"bibr16-13596535211067600","doi-asserted-by":"publisher","DOI":"10.3851\/IMP2767"},{"key":"bibr17-13596535211067600","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2015.11.009"},{"key":"bibr18-13596535211067600","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt532"},{"issue":"346","key":"bibr19-13596535211067600","first-page":"841","volume":"9","author":"Colby DA","year":"2016","journal-title":"Patent US"},{"key":"bibr20-13596535211067600","volume-title":"Tenofovir alafenamide hemifumarate","author":"Liu D","year":"2014"},{"key":"bibr21-13596535211067600","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3280b07b33"},{"key":"bibr22-13596535211067600","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3182965d45"},{"key":"bibr23-13596535211067600","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32299-7"},{"key":"bibr24-13596535211067600","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1016\/S0140-6736(17)32340-1","volume":"390","author":"Sax PE","year":"2017","journal-title":"The Lancet"},{"key":"bibr25-13596535211067600","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60616-X"},{"key":"bibr26-13596535211067600","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01089-12"},{"key":"bibr27-13596535211067600","volume-title":"Descovy (Emtricitabine\/tenofovir Alafenamide Fumarate) (Package Insert)","year":"2019"},{"key":"bibr28-13596535211067600","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.10.035"},{"key":"bibr29-13596535211067600","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.11.039"},{"key":"bibr30-13596535211067600","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30421-2"}],"container-title":["Antiviral Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13596535211067600","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13596535211067600","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13596535211067600","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:53:04Z","timestamp":1777380784000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13596535211067600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,7]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1177\/13596535211067600"],"URL":"https:\/\/doi.org\/10.1177\/13596535211067600","relation":{},"ISSN":["1359-6535","2040-2058"],"issn-type":[{"value":"1359-6535","type":"print"},{"value":"2040-2058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,7]]},"article-number":"13596535211067600"}}