{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T06:50:18Z","timestamp":1780555818982,"version":"3.54.1"},"reference-count":27,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>Adefovir, a nucleotide analog developed by John Martin, was a major breakthrough in the treatment of chronic Hepatitis B. Prior to adefovir, Hepatitis B treatment was limited to two therapeutic modalities, either interferon, which carried significant side effects and was efficacious in a minority of patients, or lamivudine which showed no durable effects with short-term use and a high rate of resistance with long-term use. Adefovir was found to be effective in suppressing viral replication and in resolving the hepatic inflammation associated with hepatitis B with only rare instances of resistance. In this article, we appreciate John Martin\u2019s contribution to science and medicine as we review the landmark trials of adefovir that brought forth a new era of treatment of Hepatitis B.<\/jats:p>","DOI":"10.1177\/13596535211067605","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T02:33:30Z","timestamp":1646102010000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Adefovir for lamivudine-resistant hepatitis B"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8175-2703","authenticated-orcid":false,"given":"Rebecca","family":"Roediger","sequence":"first","affiliation":[{"name":"Division of Liver Disease, Department of Medicine, Icahn School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth Kula","family":"Smyth","sequence":"additional","affiliation":[{"name":"Sarepta Therapeutics, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Dieterich","sequence":"additional","affiliation":[{"name":"Division of Liver Disease, Department of Medicine, Icahn School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,2,28]]},"reference":[{"key":"bibr1-13596535211067605","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12418"},{"key":"bibr2-13596535211067605","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpmed.2019.08.004"},{"key":"bibr3-13596535211067605","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910213411702"},{"key":"bibr4-13596535211067605","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.09.033"},{"key":"bibr5-13596535211067605","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-35697"},{"key":"bibr6-13596535211067605","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11100"},{"key":"bibr7-13596535211067605","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.10.4771-4779.2001"},{"key":"bibr8-13596535211067605","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20984"},{"key":"bibr9-13596535211067605","unstructured":"Liaw Y-F, Chien R-N, Yeh C-T, et al. Acute exacerbation and hepatitis B virus clearance after emergence of YMDD motif mutation during lamivudine therapy. Chang Gung Meml Hosp."},{"key":"bibr10-13596535211067605","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.04.032"},{"key":"bibr11-13596535211067605","doi-asserted-by":"publisher","DOI":"10.1086\/321879"},{"key":"bibr12-13596535211067605","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.24.2305"},{"key":"bibr13-13596535211067605","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)05840-8"},{"key":"bibr14-13596535211067605","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021812"},{"key":"bibr15-13596535211067605","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020681"},{"key":"bibr16-13596535211067605","first-page":"1419","volume":"38","author":"Schiff ER","year":"2003","journal-title":"Hepatology"},{"key":"bibr17-13596535211067605","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.10.050"},{"key":"bibr18-13596535211067605","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.10.051"},{"key":"bibr19-13596535211067605","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21534"},{"key":"bibr20-13596535211067605","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.02.019"},{"key":"bibr21-13596535211067605","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042957"},{"key":"bibr22-13596535211067605","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22414"},{"key":"bibr23-13596535211067605","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051214"},{"key":"bibr24-13596535211067605","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01073-09"},{"key":"bibr25-13596535211067605","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc066267"},{"key":"bibr26-13596535211067605","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051287"},{"key":"bibr27-13596535211067605","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051285"}],"container-title":["Antiviral Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13596535211067605","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13596535211067605","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13596535211067605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:53:04Z","timestamp":1777380784000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13596535211067605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,28]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1177\/13596535211067605"],"URL":"https:\/\/doi.org\/10.1177\/13596535211067605","relation":{},"ISSN":["1359-6535","2040-2058"],"issn-type":[{"value":"1359-6535","type":"print"},{"value":"2040-2058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,28]]},"article-number":"13596535211067605"}}