{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T04:29:30Z","timestamp":1787891370428,"version":"build-2784847793"},"reference-count":18,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>Enteroviruses can cause severe, chronic infections in patients with primary and secondary humoral immunodeficiencies. These patients may benefit from anti-enteroviral therapy. Here, we report a patient with mantle cell lymphoma treated with chemotherapy followed by autologous stem cell transplantation and rituximab maintenance therapy, who presented with echovirus 7-associated deafness and myositis leading to severe disability. She showed marked clinical improvement and enterovirus clearance from faeces and blood after treatment with intravenous immunoglobulins (IVIgs) followed by remdesivir. We demonstrated efficacy of IVIg and remdesivir against echovirus 7 using virus neutralization and cell culture assays, which supports a potential contribution to the treatment success for both therapies.<\/jats:p>","DOI":"10.1177\/13596535251385624","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T20:17:26Z","timestamp":1759954646000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Enterovirus-associated deafness and myositis in an immunocompromised patient with\n                    <i>in vivo<\/i>\n                    and\n                    <i>in vitro<\/i>\n                    efficacy of intravenous immunoglobulins and remdesivir: Case report"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5443-6264","authenticated-orcid":false,"given":"Emma M.","family":"de Koff","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Infection Prevention, Location Academic Medical Center, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harmen","family":"van Andel","sequence":"additional","affiliation":[{"name":"Department of Medicine and Department of Hematology, Location VU Medical Center, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna K.","family":"de Jong","sequence":"additional","affiliation":[{"name":"Department of Medicine and Department of Infectious Diseases, Center for Tropical Medicine and Travel Medicine, Amsterdam Public Health \u2013 Global Health, Amsterdam Institute for Immunology &amp; Infectious Diseases, Location Academic Medical Center, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneke J.","family":"van der Kooi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Myositis Expertise Center and Neuroscience Institute, Location Academic Medical Center, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlemi","family":"Calitz","sequence":"additional","affiliation":[{"name":"OrganoVIR Labs, Department of Medical Microbiology and Infection Prevention, Location Academic Medical Center, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerrit","family":"Koen","sequence":"additional","affiliation":[{"name":"OrganoVIR Labs, Department of Medical Microbiology and Infection Prevention, Amsterdam Institute for Immunology &amp; Infectious Diseases, Location Academic Medical Center, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjan J.","family":"Kwakernaak","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Clinical Immunology &amp; Allergy, and Department of Nephrology, Amsterdam Institute for Immunology &amp; Infectious Diseases, Center for Immunodeficiency and Immune Dysregulation Amsterdam, Location Academic Medical Center, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja C.","family":"Wolthers","sequence":"additional","affiliation":[{"name":"OrganoVIR Labs, Department of Medical Microbiology and Infection Prevention, Location Academic Medical Center, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2015.12.015"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2365"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000200171"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-06956-1"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2023-004036"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2019.12.018"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2024.106142"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2023.101024"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2024.105842"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2010.05.016"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/v13061028"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2013.06.039"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-12458-5"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15478"},{"issue":"11","key":"e_1_3_7_16_2","first-page":"1421","article-title":"Enteroviruses and sudden deafness","volume":"168","author":"Schattner A","year":"2003","unstructured":"Schattner A, Halperin D, Wolf D, et al. Enteroviruses and sudden deafness. CMAJ (Can Med Assoc J) 2003; 168(11): 1421\u20131423.","journal-title":"CMAJ (Can Med Assoc J)"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-29517-9"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1135834"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofaf212"}],"container-title":["Antiviral Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13596535251385624","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13596535251385624","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13596535251385624","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:53:25Z","timestamp":1777380805000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13596535251385624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1177\/13596535251385624"],"URL":"https:\/\/doi.org\/10.1177\/13596535251385624","relation":{},"ISSN":["1359-6535","2040-2058"],"issn-type":[{"value":"1359-6535","type":"print"},{"value":"2040-2058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"article-number":"13596535251385624"}}