{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T18:16:29Z","timestamp":1785348989988,"version":"3.55.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2012,10,8]],"date-time":"2012-10-08T00:00:00Z","timestamp":1349654400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Autism"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Parental concerns persist that immunization increases the risk of autism spectrum disorder, resulting in the potential for reduced uptake by parents of younger siblings of children with autism spectrum disorder (\u201cyounger sibs\u201d).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To compare immunization uptake by parents for their younger child relative to their older child with autism spectrum disorder (\u201cproband\u201d) and controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Immunization status was obtained for 98 \u201cyounger sibs,\u201d 98 \u201cprobands,\u201d and 65 controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A significant group difference emerged for overall immunization status (Fisher\u2019s exact test = 62.70, p &lt; .001). One or more immunizations in 59\/98 younger sibs were delayed (47\/98; 48%) or declined (12\/98; 12.2%); immunizations were delayed in 16\/98 probands (16.3%) and declined in only one. All controls were fully immunized, with only 6 (9.2%) delayed. Within the \u201cyounger sibs\u201d group, 25\/98 received an autism spectrum disorder diagnosis; 7 of whom (28%) were fully immunized. The rates of autism spectrum disorder diagnosis did not differ between immunized and nonimmunized younger sib groups, although small sample size limits interpretability of this result.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Parents who already have one child with autism spectrum disorder may delay or decline immunization for their younger children, potentially placing them at increased risk of preventable infectious diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1362361312459111","type":"journal-article","created":{"date-parts":[[2012,10,9]],"date-time":"2012-10-09T01:00:26Z","timestamp":1349744426000},"page":"148-155","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Immunization uptake in younger siblings of children with autism spectrum disorder"],"prefix":"10.1177","volume":"18","author":[{"given":"Ghassan Abu","family":"Kuwaik","sequence":"first","affiliation":[{"name":"University of Toronto, Canada"},{"name":"Hospital for Sick Children, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Roberts","sequence":"additional","affiliation":[{"name":"University of Toronto, Canada"},{"name":"Hospital for Sick Children, Canada"},{"name":"Bloorview Research Institute, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lonnie","family":"Zwaigenbaum","sequence":"additional","affiliation":[{"name":"University of Alberta, Canada"},{"name":"Glenrose Rehabilitation Hospital, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Bryson","sequence":"additional","affiliation":[{"name":"Dalhousie University, Canada"},{"name":"IWK Health Centre, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel M","family":"Smith","sequence":"additional","affiliation":[{"name":"Dalhousie University, Canada"},{"name":"IWK Health Centre, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Szatmari","sequence":"additional","affiliation":[{"name":"McMaster University, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie M","family":"Modi","sequence":"additional","affiliation":[{"name":"Hospital for Sick Children, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Tanel","sequence":"additional","affiliation":[{"name":"Holland Bloorview Kids Rehabilitation Hospital, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Brian","sequence":"additional","affiliation":[{"name":"University of Toronto, Canada"},{"name":"Bloorview Research Institute, Canada"},{"name":"Holland Bloorview Kids Rehabilitation Hospital, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,10,8]]},"reference":[{"key":"bibr1-1362361312459111","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38989.445845.7C"},{"key":"bibr2-1362361312459111","unstructured":"Canadian Paediatric Society (2008) MMR vaccine: myths and facts. 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