{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T05:41:44Z","timestamp":1791610904928,"version":"4.3.4"},"reference-count":86,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T00:00:00Z","timestamp":1602028800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010767","name":"Innovative Medicines Initiative","doi-asserted-by":"publisher","award":["115300 \/ 777394"],"award-info":[{"award-number":["115300 \/ 777394"]}],"id":[{"id":"10.13039\/501100010767","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Autism"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>Previous studies have reported reduced quality of life in autism. Improving quality of life for autistic people is, therefore, a key priority for clinical research and practice. However, the relative impact of core autism traits (e.g. social-communication difficulties), as compared to associated mental health symptoms (e.g. anxiety, depression) on quality of life remains poorly understood. This is despite at least 20%\u201350% of autistic individuals experiencing associated anxiety and\/or depression symptoms. Hence, we measured subjective quality of life in 573 six to thirty-year-olds (autism spectrum disorder N\u2009=\u2009344), using two widely validated questionnaires. Adults self-reported on the World Health Organization Quality of Life\u2013Brief instrument. Parents of children\/adolescents completed the Child Health and Illness Profile. We assessed individual variability across both measures and modelled associations between quality of life, core autism traits, anxiety, and depression symptoms. Across both age groups and quality of life measures, autistic individuals scored lower than comparison individuals, on average, particularly for physical health in adults ( d\u2009=\u2009\u22121.24, 95% confidence interval: [\u22121.56, \u22120.93]) and school achievement for children\/adolescents ( d\u2009=\u2009\u22121.06, 95% confidence interval: [\u22121.29, \u22120.84]). However, a notable proportion of autistic individuals (36%\u201371% across quality of life domains) did not have reduced quality of life. Across ages and quality of life measures, severity of associated symptoms was significantly related to reduced quality of life on several domains, after accounting for core autism traits. Most notably, depression symptoms were related to reduced physical\/psychological well-being in both adults ( \u03b2\u2009\u2a7e\u2009\u22120.34) and children\/adolescents ( \u03b2\u2009=\u2009\u22120.29, 95% confidence interval: [\u22120.36, \u22120.14]). For children\/adolescents, anxiety symptoms ( \u03b2\u2009\u2a7e\u2009\u22120.28) and core social-communication difficulties ( \u03b2\u2009\u2a7e\u2009\u22120.22) were also related to subjective quality of life outcomes. Overall, findings indicate that not all autistic individuals experience reduced subjective quality of life. Variability in quality of life is significantly influenced by associated symptoms, across developmental stage. This may provide a tractable target for mental health services to improve quality of life for autistic individuals over the lifespan.<\/jats:p>\n                  <jats:sec>\n                    <jats:title>Lay abstract<\/jats:title>\n                    <jats:p>Previous studies suggest that some autistic individuals report lower satisfaction, or well-being, with different aspects of everyday life than those without autism. It is unclear whether this might be partly explained by symptoms of anxiety and\/or depression, which affect at least 20%\u201350% of autistic people. In this study, we measured individual differences in well-being in 573 six to thirty-year-olds with and without a diagnosis of autism. We investigated whether individual differences in well-being were explained by autism traits (e.g. social-communication difficulties) and\/or anxiety and depression symptoms. We showed that, though well-being was lower for some autistic individuals, compared to those without autism, many autistic individuals reported good well-being. Where well-being was reduced, this was particularly explained by depression symptoms, across all ages. For children\/adolescents, anxiety and social-communication difficulties were also related to some aspects of well-being. Our study suggests that support and services for improving mental health, especially depression symptoms, may also improve broader outcomes for autistic people.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1362361320959959","type":"journal-article","created":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T03:07:25Z","timestamp":1602040045000},"page":"389-404","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":133,"title":["How do core autism traits and associated symptoms relate to quality of life? Findings from the Longitudinal European Autism Project"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1968-134X","authenticated-orcid":false,"given":"Bethany FM","family":"Oakley","sequence":"first","affiliation":[{"name":"King\u2019s College London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Tillmann","sequence":"additional","affiliation":[{"name":"King\u2019s College London, UK"},{"name":"University of Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jumana","family":"Ahmad","sequence":"additional","affiliation":[{"name":"King\u2019s College London, UK"},{"name":"University of Greenwich, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisy","family":"Crawley","sequence":"additional","affiliation":[{"name":"King\u2019s College London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"San Jos\u00e9 C\u00e1ceres","sequence":"additional","affiliation":[{"name":"King\u2019s College London, UK"},{"name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Holt","sequence":"additional","affiliation":[{"name":"University of Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1993-6549","authenticated-orcid":false,"given":"Tony","family":"Charman","sequence":"additional","affiliation":[{"name":"King\u2019s College London, UK"},{"name":"South London and Maudsley NHS Foundation Trust (SLaM), UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4595-1144","authenticated-orcid":false,"given":"Tobias","family":"Banaschewski","sequence":"additional","affiliation":[{"name":"Universit\u00e4t Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Buitelaar","sequence":"additional","affiliation":[{"name":"Radboud University Nijmegen Medical Center, The Netherlands"},{"name":"Karakter Child and Adolescent Psychiatry University Center, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5450-0823","authenticated-orcid":false,"given":"Emily","family":"Simonoff","sequence":"additional","affiliation":[{"name":"King\u2019s College London, UK"},{"name":"South London and Maudsley NHS Foundation Trust (SLaM), UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Declan","family":"Murphy","sequence":"additional","affiliation":[{"name":"King\u2019s College London, UK"},{"name":"South London and Maudsley NHS Foundation Trust (SLaM), UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Loth","sequence":"additional","affiliation":[{"name":"King\u2019s College London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,10,7]]},"reference":[{"key":"bibr1-1362361320959959","doi-asserted-by":"crossref","unstructured":"Adams D., Clark M., Keen D. 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