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In South Africa, individuals may be at elevated risk for depression due to HIV and AIDS, violence, and poverty. For adolescents, resilience-focused prevention strategies have the potential to reduce onset of depression. Involving families in promoting adolescent mental health is developmentally appropriate, but few existing interventions take a family approach to prevention of adolescent depression. We conducted a qualitative investigation from 2013\u20132015 to inform the development of a family intervention to prevent adolescent depression in South Africa among families infected or at risk for HIV. Using focus groups with adolescents and parents (eight groups, n\u2009=\u200957), and interviews (n\u2009=\u200925) with clinicians, researchers, and others providing mental health and related services, we identified context-specific factors related to risk for family depression, and explored family interactions around mental health more broadly as well as depression specifically. Findings indicate that HIV and poverty are important risk factors for depression. Future interventions must address linguistic complexities in describing and discussing depression, and engage with the social interpretations and meanings placed upon depression in the South African context, including bewitchment and deviations from prescribed social roles. Participants identified family meetings as a context-appropriate prevention strategy. Family meetings offer opportunities to practice family problem solving, involve other family members in communal parenting during periods of parental depression, and serve as forums for building Xhosa-specific interpretations of resilience. This study will guide the development of Our Family Our Future, a resilience-focused family intervention to prevent adolescent depression (ClinicalTrials.gov #NCT02432352). <\/jats:p>","DOI":"10.1177\/1363461518799510","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T13:08:48Z","timestamp":1538744928000},"page":"187-212","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Building resilient families: Developing family interventions for preventing adolescent depression and HIV in low resource settings"],"prefix":"10.1177","volume":"56","author":[{"given":"Caroline","family":"Kuo","sequence":"first","affiliation":[{"name":"Brown University and University of Cape Town"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashleigh","family":"LoVette","sequence":"additional","affiliation":[{"name":"Brown University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan J.","family":"Stein","sequence":"additional","affiliation":[{"name":"University of Cape Town"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie D.","family":"Cluver","sequence":"additional","affiliation":[{"name":"University of Oxford and University of Cape Town"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry K.","family":"Brown","sequence":"additional","affiliation":[{"name":"Rhode Island Hospital and Brown University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Millicent","family":"Atujuna","sequence":"additional","affiliation":[{"name":"Desmond Tutu HIV Foundation and University of Cape Town"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy R.G.","family":"Gladstone","sequence":"additional","affiliation":[{"name":"Wellesley College, Boston Children's Hospital and Judge Baker Children's Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Martin","sequence":"additional","affiliation":[{"name":"Boston Children\u2019s Hospital and Judge Baker Children's Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Beardslee","sequence":"additional","affiliation":[{"name":"Judge Baker Children\u2019s Center, Harvard University and Boston Children's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,10,5]]},"reference":[{"key":"bibr1-1363461518799510","doi-asserted-by":"publisher","DOI":"10.1017\/S003329179700593X"},{"key":"bibr2-1363461518799510","doi-asserted-by":"publisher","DOI":"10.1016\/j.chc.2011.12.001"},{"key":"bibr3-1363461518799510","doi-asserted-by":"publisher","DOI":"10.1176\/ps.62.3.pss6203_0247"},{"key":"bibr4-1363461518799510","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199811000-00012"},{"key":"bibr5-1363461518799510","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780199638963.003.0005"},{"key":"bibr6-1363461518799510","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2012.02613.x"},{"key":"bibr7-1363461518799510","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199611000-00011"},{"key":"bibr8-1363461518799510","unstructured":"Cape Town Government (2014). 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