{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T12:29:04Z","timestamp":1784204944932,"version":"3.55.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clinical Hemorheology and Microcirculation"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To investigate the possible correlation between changes in haemorheology and the HIF-1\/EPO pathway in children with\n                      <jats:italic>Mycoplasma pneumoniae<\/jats:italic>\n                      pneumonia (MPP) to provide new ideas for the early clinical identification of hypercoagulability and reduce the incidence of thrombosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 205 children with newly diagnosed MPP were selected from our department and divided into a general MPP group (100 patients) and a severe MPP group (105 patients) according to diagnostic criteria. In addition, 30 healthy children were selected as the control group. Routine blood and coagulation function data were collected, and the expression levels of T-cell factors, HIF-1\u03b1, EPO and haemorheology were detected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The levels of D-dimer, FDP and fibrinogen in the MPP group were significantly greater than those in the control group and more obvious in the severe group than in the general group. Compared with those in the control group, the whole blood viscosity (low, medium, high tangential), plasma viscosity, whole blood low tangential reductive viscosity and erythrocyte aggregation index in the haemorheology of children in the MPP group were significantly greater, and the range of increase in the severe group was greater than those in the general group. The red blood cell (RBC) count and haematocrit (HCT) of children in the MPP group were significantly greater than those in the control group at admission and were more altered in the severe group than in the general group. Moreover, the serum expression levels of TNF-a, IFN-\u03b3, IL-6, IL-8, IL-10, IL-17, HIF-1\u03b1 and EPO in the MPP group were significantly greater than those in the healthy control group. With the exception of IFN-\u03b3, the cytokines levels in the severe group were significantly greater than those in the general group. The expression level of HIF-1\u03b1 was significantly correlated with the elevated levels of TNF-a, IL-6 and IL-8.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hypercoagulability occurs during the course of MPP in children, especially those with severe disease. The increase in blood viscosity may be an important reason for hypercoagulability, and highly inflammatory cytokines such as TNF-a, IL-6 and IL-8 in children may increase the RBC and HCT levels by activating the HIF-1\u03b1\/EPO pathway, which may lead to changes in haemorheology and thus participate in the development of hypercoagulability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13860291251313591","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T23:56:34Z","timestamp":1742946994000},"page":"348-355","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Correlation between changes in haemorheology and the HIF-1\/EPO pathway in children with\n                    <i>Mycoplasma pneumoniae<\/i>\n                    pneumonia"],"prefix":"10.1177","volume":"89","author":[{"given":"Bin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound in Medicine, Xuzhou New Health Hospital, (Jiangsu Provincial People's Hospital Xuzhou Branch), Xuzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Jian","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Jun","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"696","article-title":"Advancement in epidemiology of Mycoplasma pneumoniae pneumonia in children in China","volume":"62","author":"Liu K","year":"2024","unstructured":"Liu K, Fu HM, Lu Q. Advancement in epidemiology of Mycoplasma pneumoniae pneumonia in children in China. Zhonghua Er Ke Za Zhi 2024; 62: 696\u2013699.","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/crj.13584"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2023.105291"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfac224"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2023.110808"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-023-01662-0"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000004287"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-010-0044-X"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-023-04188-7"},{"key":"e_1_3_3_11_2","first-page":"79","article-title":"Children's mycoplasma pneumoniae pneumonia guidelines (2023 edition)","volume":"50","author":"National Health Commission of the People's Republic of China","year":"2023","unstructured":"National Health Commission of the People's Republic of China. Children's mycoplasma pneumoniae pneumonia guidelines (2023 edition). Int J Infect Dis Epidemiol 2023; 50: 79\u201385.","journal-title":"Int J Infect Dis Epidemiol"},{"key":"e_1_3_3_12_2","first-page":"486","article-title":"Risk factors for embolism in children with refractory Mycoplasmapneumoniae pneumonia and construction of a nomogram model for prediction of embolism","volume":"26","author":"Xie LN","year":"2024","unstructured":"Xie LN, Feng T, Guo YJ, et al. Risk factors for embolism in children with refractory Mycoplasmapneumoniae pneumonia and construction of a nomogram model for prediction of embolism. Zhongguo Dang Dai Er Ke Za Zhi 2024; 26: 486\u2013492.","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-020-4774-9"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2021.05.013"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.106.027029"},{"key":"e_1_3_3_16_2","first-page":"521","article-title":"HIF-1: structure, biology and natural modulators","volume":"19","author":"Yang C","year":"2021","unstructured":"Yang C, Zhong ZF, Wang SP, et al. HIF-1: structure, biology and natural modulators. Chin J Nat Med 2021; 19: 521\u2013527.","journal-title":"Chin J Nat Med"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114802"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-02020-z"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2024.2324078"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/crj.13620"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-022-00513-w"}],"container-title":["Clinical Hemorheology and Microcirculation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13860291251313591","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13860291251313591","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13860291251313591","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:07:06Z","timestamp":1777388826000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13860291251313591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,25]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1177\/13860291251313591"],"URL":"https:\/\/doi.org\/10.1177\/13860291251313591","relation":{},"ISSN":["1386-0291","1875-8622"],"issn-type":[{"value":"1386-0291","type":"print"},{"value":"1875-8622","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,25]]}}}