{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:22:14Z","timestamp":1777497734618,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clinical Hemorheology and Microcirculation"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A non-invasive and reliable method is essential for diagnosing sub-1 cm thyroid lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We have developed a nomogram that integrates ultrasound features and clinical risk factors to effectively diagnosed sub-1 cm thyroid lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Our study included 406 patients with sub-1 cm thyroid lesions. We collected their demographic data and ultrasound characteristics of the thyroid, followed by conducting univariate and multivariate analyses to identify the risk factors. Subsequently, we developed a nomogram for predicting sub-1 cm thyroid lesions, comparing its diagnostic performance with that of American College of Radiology TIRADS (ACR TI-RADS) and Chinese Thyroid Imaging Reporting and Data Systems (C TI-RADS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Six variables, including female gender, capsular invasion, solid composition, aspect ratio &gt;1, irregular margin and microcalcification, were identified as potential predictors and used to develop a predictive nomogram. Receiver operating characteristic curves were constructed and compared with ACR TI-RADS and C TI-RADS classifications. The area under the curve of the nomogram was found to be at 0.85, while the AUC of ACR TI-RADS classification and C TI-RADS classification were at 0.771 and 0 .736 respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>By utilizing this user-friendly nomogram, the likelihood of sub-1 cm malignancy in thyroid lesions can be objectively quantified.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13860291251324565","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T12:50:04Z","timestamp":1742388604000},"page":"340-347","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A nomogram based on clinical and ultrasound features to identify sub-1\u2005cm benign and malignant thyroid lesions"],"prefix":"10.1177","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8880-2517","authenticated-orcid":false,"given":"Ruo-ting","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Ultrasound, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8972-7668","authenticated-orcid":false,"given":"Jia-jia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Interventional Ultrasound, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7220-2275","authenticated-orcid":false,"given":"Yu-xia","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9943-5625","authenticated-orcid":false,"given":"Jia-fan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3022-0341","authenticated-orcid":false,"given":"Huan-bin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1283-0266","authenticated-orcid":false,"given":"Zhe","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Interventional Ultrasound, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"1260","article-title":"Progress and challenges in thyroid cancer management","volume":"27","author":"Haymart MR","year":"2021","unstructured":"Haymart MR. 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