{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:59:34Z","timestamp":1789545574225,"version":"build-2803163510"},"reference-count":23,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clinical Hemorheology and Microcirculation"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Laparoscopic surgery is widely used in the field of clinical surgery due to its minimal trauma, minimal bleeding, short hospital stay, and fast postoperative recovery. There were several studies found that elderly patients undergoing laparoscopic surgery are more prone to coagulation disorders, increased blood viscosity, and the influence of CO\n                      <jats:sub>2<\/jats:sub>\n                      pneumoperitoneum, which can easily lead to changes in blood rheology There are no studies have investigated the effects on blood rheology of general anesthesia combined with epidural block on hemorheology in elderly patients undergoing laparoscopic radical resection of rectal cancer. This trial investigated to explore the effect of general anesthesia combined with epidural block on blood rheology in elderly patients undergoing laparoscopic radical resection of rectal cancer, providing experimental basis for clinical anesthesia to regulate blood rheology characteristics and prevent hyperviscosity and its complications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 60 patients undergoing laparoscopic radical resection of colorectal cancer\n                      <jats:bold>,<\/jats:bold>\n                      aged 60\u201375 years, with American Society of Anesthesiologists physical status III, were enrolled in this study. All the subjects were randomly divided into general anesthesia group (group G, n\u2009=\u200930) and general anesthesia in combination with epidural block group (group G\u2009+\u2009E, n\u2009=\u200930) according to a random number table. Patients in the group G received the general anesthesia alone while those in the group G\u2009+\u2009E were given the combined epidural block based on anesthetic method of group G. The arterial blood gas indexes (pH, PaCO\n                      <jats:sub>2<\/jats:sub>\n                      and HCO\n                      <jats:sub>3<\/jats:sub>\n                      <jats:sup>\u2212<\/jats:sup>\n                      ) and hemodynamic indexes(H\u014b\n                      <jats:sub>b<\/jats:sub>\n                      , L\u014b\n                      <jats:sub>b<\/jats:sub>\n                      ,\u03b7\n                      <jats:sub>p<\/jats:sub>\n                      , EAI, Hct and ESR) were measured at four time points: before induction of general anesthesia (T\n                      <jats:sub>0<\/jats:sub>\n                      ), 5\u2005min before establishment of pneumoperitoneum (T\n                      <jats:sub>1<\/jats:sub>\n                      ), 30\u2005min after establishment of pneumoperitoneum (T\n                      <jats:sub>2<\/jats:sub>\n                      ) and 30\u2005min after elimination of pneumoperitoneum (T\n                      <jats:sub>3<\/jats:sub>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was no significant statistical difference (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05) in pH, PaCO\n                      <jats:sub>2<\/jats:sub>\n                      , and HCO\n                      <jats:sub>3<\/jats:sub>\n                      <jats:sup>\u2212<\/jats:sup>\n                      between the two groups at T\n                      <jats:sub>1<\/jats:sub>\n                      , T\n                      <jats:sub>2<\/jats:sub>\n                      , and T\n                      <jats:sub>3<\/jats:sub>\n                      . At T\n                      <jats:sub>0<\/jats:sub>\n                      , there was no significant difference (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05) in H\u014b\n                      <jats:sub>b<\/jats:sub>\n                      , L\u014b\n                      <jats:sub>b<\/jats:sub>\n                      , \u03b7\n                      <jats:sub>p<\/jats:sub>\n                      , Erythrocyte Aggregation Index (EAI), Hct, and Erythrocyte Sedimentation Rate (ESR) between the two groups. However, these indices were significantly lower in group G\u2009+\u2009E than in group G (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) at T\n                      <jats:sub>1<\/jats:sub>\n                      , T\n                      <jats:sub>2<\/jats:sub>\n                      , and T\n                      <jats:sub>3<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Combining general anesthesia with epidural block can effectively reduce the hemorheological indexes of patients and improve the hemorheological state in elderly patients with malignant tumors undergoing laparoscopic surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13860291251335469","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T03:21:40Z","timestamp":1747106500000},"page":"39-44","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of general anesthesia combined with epidural block on hemorheology in elderly patients with laparoscopic radical resection of colorectal cancer: A randomized controlled trial"],"prefix":"10.1177","volume":"90","author":[{"given":"Jing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China"},{"name":"Department of Anesthesiology, People's Hospital of Yilong County, Nanchong, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanqiu","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, People's Hospital of Yilong County, Nanchong, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bencui","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, People's Hospital of Dayi County, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2083-2854","authenticated-orcid":false,"given":"Biqian","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"48","article-title":"Laparoscopic approach has benefits in gynecological emergencies - even for massive hemoperitoneum","volume":"111","author":"Beuran M","year":"2016","unstructured":"Beuran M, Negoi I, Hostiuc S, et al. 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