{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:25:23Z","timestamp":1777497923073,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clinical Hemorheology and Microcirculation"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sacubitril is an important and effective agent for cardiovascular remodeling. This study aims to evaluate its proangiogenic effects in an experimental model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The chorioallantoic membrane (CAM) model was created for the investigation of the proangiogenic potential of sacubitril with different therapeutic doses (10\n                      <jats:sup>\u22127<\/jats:sup>\n                      M, 10\n                      <jats:sup>\u22126<\/jats:sup>\n                      M, 10\n                      <jats:sup>\u22125<\/jats:sup>\n                      M) and compared with drug-free pellet group (sham) and normal morphology (control) of chick embryo development in drug-free chick embryos. The developing embryo's vascularity and the pellets\u2019 effect were evaluated under a stereoscopic microscope. The density of vascular shoots and newly formed vascular nodules were not recorded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was no significant difference between the control and drug-free pellet groups (12.4\u2009\u00b1\u20092.8 vs. 14.1\u2009\u00b1\u20091.3 junctions per ROI, p\u2009=\u20090.48). The incremental angiogenic properties were detected in drug groups as follows: 15.3\u2009\u00b1\u20093.8 per ROI in Group I (10\n                      <jats:sup>\u22127<\/jats:sup>\n                      M concentration); 21.6\u2009\u00b1\u20095.4 per ROI in Group II (10\n                      <jats:sup>\u22126<\/jats:sup>\n                      M concentration); 22.9\u2009\u00b1\u20098.1 per ROI in Group III (10\n                      <jats:sup>\u22125<\/jats:sup>\n                      M concentration) (p\u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings support that sacubitril provokes angiogenesis in a dose-dependent manner. Investigating these properties can be useful for understanding further effects of this agent in other cardiovascular diseases. Therapeutic angiogenesis is important for ameliorating the results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13860291251352350","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T03:18:10Z","timestamp":1751944690000},"page":"116-121","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Experimental investigation of proangiogenic properties of sacubitril on a chorio allantoic membrane model"],"prefix":"10.1177","volume":"90","author":[{"given":"Mustafa","family":"Ozgul","sequence":"first","affiliation":[{"name":"Department of Cardiology, Alanya Training and Research Hospital, Antalya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyup","family":"Aydogan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Medical School of Alaaddin Keykubat University, Antalya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,7,8]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.300507"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-018-1185-6"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2020.111363"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.04.060"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.08556"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.21037\/cdt.2018.05.10"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.10224"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9916789"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.144.suppl_1.12035"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-42113-0"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccao.2020.09.007"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2024-088744"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1069828"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2021.12041"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.3233\/CH-201028"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.3233\/CH-131697"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.5606\/tgkdc.dergisi.2021.22212"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-35474-5"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389201003379040"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2020.0048"},{"key":"e_1_3_2_22_2","first-page":"131","article-title":"The investigation of the antiangiogenic potential of amiodarone HCl in the chick embryo chorioallantoic membrane model","volume":"24","author":"Karahan O","year":"2013","unstructured":"Karahan O, Yavuz C, Demirtas S, et al. The investigation of the antiangiogenic potential of amiodarone HCl in the chick embryo chorioallantoic membrane model. Biomed Res 2013; 24: 131\u2013134.","journal-title":"Biomed Res"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000000019"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/2040622316665350"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00426"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-32773-9"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M602490200"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173727"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/1060028020983522"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.08.737"}],"container-title":["Clinical Hemorheology and Microcirculation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13860291251352350","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13860291251352350","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13860291251352350","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:07:31Z","timestamp":1777388851000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13860291251352350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1177\/13860291251352350"],"URL":"https:\/\/doi.org\/10.1177\/13860291251352350","relation":{},"ISSN":["1386-0291","1875-8622"],"issn-type":[{"value":"1386-0291","type":"print"},{"value":"1875-8622","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]}}}