{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:24:40Z","timestamp":1777497880628,"version":"3.51.4"},"reference-count":53,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clinical Hemorheology and Microcirculation"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Steatosis hepatis is of outstanding clinical importance. The aim of this study was to apply the new parametric method \u201cUltrasound Derived Fat Fraction\u201d (UDFF) to monitor changes of liver fat in obese patients undergoing weight loss measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In 53 obese patients BMI, absolute body fat, waist circumference and UDFF were measured before and after a three-month weight loss intervention. UDFF measurements were performed using a Siemens ultrasound system (DAX, 1.0\u20133.5 Mz). We analysed the correlation of change in BMI (\u2265\u22121 vs\u2009&lt;\u2009\u22121), body fat (\u2265\u22122\u2005kg vs\u2009&lt;\u2009\u22122\u2005kg) and waist circumference (\u2265\u221210\u2005cm vs\u2009&lt;\u2009\u221210\u2005cm) with the change in UDFF (\u2265\u221230% vs\u2009&lt;\u2009\u221230%) (significance level:\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.0167).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At baseline, mean BMI was 39.2 (range: 29.8\u201363.6), body fat 51.3\u2005kg (range: 29.9\u2013111.7), waist circumference 120.2\u2005cm (range: 95\u2013164) and UDFF 26% (range: 7\u201341%). 54.7% of patients lost at least 2\u2005kg of body fat. These patients were significantly more likely to have a reduction in UDFF of at least 30% (\u22652\u2005kg fat: 58.6% vs.\u2009&lt;\u20092\u2005kg fat: 20.8%;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.011). For BMI and waist circumference changes no significant correlation with UDFF was observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study underlines that UDFF could be a promising, non-invasive tool to monitor changes in liver fat.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13860291251376519","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T18:06:09Z","timestamp":1757959569000},"page":"39-46","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Ultrasound derived fat fraction indicates reduction of liver fat content after lifestyle modification in obese patients"],"prefix":"10.1177","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9619-6647","authenticated-orcid":false,"given":"Marcel","family":"Vetter","sequence":"first","affiliation":[{"name":"Friedrich-Alexander-University Erlangen-N\u00fcrnberg and Universit\u00e4tsklinikum"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3030-071X","authenticated-orcid":false,"given":"Leonie","family":"Burgard","sequence":"additional","affiliation":[{"name":"Friedrich-Alexander-University Erlangen-N\u00fcrnberg and Universit\u00e4tsklinikum"},{"name":"Hector-Center for Nutrition, Exercise and Sports, Department of Medicine 1, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Jesper","sequence":"additional","affiliation":[{"name":"Friedrich-Alexander-University Erlangen-N\u00fcrnberg and Universit\u00e4tsklinikum"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Fischer","sequence":"additional","affiliation":[{"name":"Friedrich-Alexander-University Erlangen-N\u00fcrnberg and Universit\u00e4tsklinikum"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Klett","sequence":"additional","affiliation":[{"name":"Friedrich-Alexander-University Erlangen-N\u00fcrnberg and Universit\u00e4tsklinikum"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricarda","family":"Lamprecht-Bailer","sequence":"additional","affiliation":[{"name":"Friedrich-Alexander-University Erlangen-N\u00fcrnberg and Universit\u00e4tsklinikum"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Haberkamp","sequence":"additional","affiliation":[{"name":"Friedrich-Alexander-University Erlangen-N\u00fcrnberg and Universit\u00e4tsklinikum"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus Friedrich","family":"Neurath","sequence":"additional","affiliation":[{"name":"Friedrich-Alexander-University Erlangen-N\u00fcrnberg and Universit\u00e4tsklinikum"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yurdagul","family":"Zopf","sequence":"additional","affiliation":[{"name":"Friedrich-Alexander-University Erlangen-N\u00fcrnberg and Universit\u00e4tsklinikum"},{"name":"Hector-Center for Nutrition, Exercise and Sports, Department of Medicine 1, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deike","family":"Strobel","sequence":"additional","affiliation":[{"name":"Friedrich-Alexander-University Erlangen-N\u00fcrnberg and Universit\u00e4tsklinikum"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,15]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.191707"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-1880-2283"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.05.036"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2024.04.031"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2022.07.003"},{"key":"e_1_3_2_7_2","article-title":"EFSUMB Guidelines and recommendations on the clinical use of liver ultrasound elastography, update 2017 (long version)","volume":"38","author":"Dietrich CF","year":"2017","unstructured":"Dietrich CF, Bamber J, Berzigotti A, et al. EFSUMB Guidelines and recommendations on the clinical use of liver ultrasound elastography, update 2017 (long version). Ultraschall Med 2017; 38: e16\u2013e47.","journal-title":"Ultraschall Med"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.210736"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i40.6053"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2024.03.014"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20701"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-021-00584-0"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200102153440706"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29797"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.09.001"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.3233\/CH-239100"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00117-012-2307-2"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2006.03.021"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.01.008"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2021.06.002"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1109\/JTEHM.2020.3001488"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(20)30357-5"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/13860291241304057"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.11.003"},{"key":"e_1_3_2_25_2","unstructured":"Liver ultrasound derived fat fraction (UDFF) white paper https:\/\/www.siemens-healthineers.com\/en-us\/ultrasound\/new-era-ultrasound\/acuson-sequoia\/udff-liver-whitepaper (accessed 11 November 2024)."},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.220606"},{"key":"e_1_3_2_27_2","article-title":"A comparison of uremic pruritus in patients receiving peritoneal dialysis and hemodialysis","volume":"95","author":"Wu H-Y","year":"2016","unstructured":"Wu H-Y, Peng Y-S, Chen H-Y, et al. A comparison of uremic pruritus in patients receiving peritoneal dialysis and hemodialysis. Medicine (Baltimore) 2016; 95: e2935.","journal-title":"Medicine (Baltimore)"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063543"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-024-01775-1"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2024.09.002"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-024-11119-2"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/osp4.476"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-019-0961-9"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10396-024-01472-6"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1618857"},{"key":"e_1_3_2_36_2","volume-title":"WHO guidelines on physical activity and sedentary behaviour","year":"2020","unstructured":"WHO guidelines on physical activity and sedentary behaviour. 1st ed. Geneva: World Health Organization, 2020.","edition":"1"},{"key":"e_1_3_2_37_2","article-title":"M\u00f6glichkeiten und grenzen der quantifikation des fettgehaltes der leber: analyse der wichtigsten einflussfaktoren (confounding factors)","volume":"45","author":"Lessenich P","year":"2024","unstructured":"Lessenich P, Labyed Y, Kubale R, et al. M\u00f6glichkeiten und grenzen der quantifikation des fettgehaltes der leber: analyse der wichtigsten einflussfaktoren (confounding factors) Ultraschall in der Medizin. Thieme Verlag 2024; 45: S9\u2013S10.","journal-title":"Ultraschall in der Medizin. Thieme Verlag"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/jum.15364"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-019-06072-4"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e3283650650"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.4016"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.3233\/CH-249103"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2023.11.034"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.14366\/usg.21150"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.3233\/CH-248111"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.11152\/mu-2688"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.23.30775"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13244-024-01834-1"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.3233\/CH-238102"},{"key":"e_1_3_2_50_2","article-title":"Ultrasound-derived fat fraction for diagnosing hepatic steatosis: a systematic review and meta-analysis","volume":"86","author":"Verdan S","year":"2025","unstructured":"Verdan S, Torri GB, Marcos VN, et al. Ultrasound-derived fat fraction for diagnosing hepatic steatosis: a systematic review and meta-analysis Eur Radiol 2025; 86.","journal-title":"Eur Radiol"},{"key":"e_1_3_2_51_2","doi-asserted-by":"crossref","unstructured":"Hauner H Wirth A (eds) (2024) Adipositas: \u00c4tiologie Folgekrankheiten Diagnostik Therapie.","DOI":"10.1007\/978-3-662-58895-6"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.08.061"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.3233\/CH-151990"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.3233\/CH-168112"}],"container-title":["Clinical Hemorheology and Microcirculation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13860291251376519","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13860291251376519","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13860291251376519","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:07:35Z","timestamp":1777388855000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13860291251376519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1177\/13860291251376519"],"URL":"https:\/\/doi.org\/10.1177\/13860291251376519","relation":{},"ISSN":["1386-0291","1875-8622"],"issn-type":[{"value":"1386-0291","type":"print"},{"value":"1875-8622","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]}}}