{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T06:45:01Z","timestamp":1782629101104,"version":"3.54.5"},"reference-count":42,"publisher":"SAGE Publications","issue":"1-2","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clinical Hemorheology and Microcirculation"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to investigate the effect of pancreatic ductal adenocarcinoma (PDAC) on the RBCs rheological properties at the time of diagnosis and to examine their potential relationship with tumor stage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      We studied 32 patients with confirmed PDAC.The aggregation and deformability of RBCs were evaluated using a LORCA.The following parameters specific to the aggregation process were estimated: the aggregation index (AI), the aggregation half-time (t\n                      <jats:sub>1\/2<\/jats:sub>\n                      ), and the threshold shear rate (\u03b3\n                      <jats:sub>thr<\/jats:sub>\n                      ).RBC deformability expressed as erythrocyte elongation (EI), was measured from 0.3\u2005Pa to 60\u2005Pa shear stresses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All measured RBC aggregation parameters among PDAC subjects differed from those in controls. The AI (P\u2009&lt;\u20090.03) was significantly higher in the PDAC group, whereas t\n                      <jats:sub>1\/2<\/jats:sub>\n                      (P\u2009&lt;\u20090.001) and AMP (P\u2009&lt;\u20090.001) were significantly lower compared to the control group. No significant differences in RBC deformability were observed between the PDAC and control groups.There were significant correlations between some RBC aggregation parameters and PDAC tumor staging (T).There was that T correlated positively with t\n                      <jats:sub>1\/2<\/jats:sub>\n                      , and negatively with AI and \u03b3\n                      <jats:sub>thr.<\/jats:sub>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PDAC is associated with alterations in RBC rheology behavior. Results indicated a higher tendency for RBC aggregation and aggregate stability associated with the rigidity of RBC at lower shear stress.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13860291261432433","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T12:24:44Z","timestamp":1775823884000},"page":"35-42","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Alterations in the red blood cell rheology in pancreatic cancer"],"prefix":"10.1177","volume":"92","author":[{"given":"Maciej","family":"Wiewiora","sequence":"first","affiliation":[{"name":"Department of General Surgery, Vascular Surgery, Angiology and Phlebology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Silesia, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad","family":"Karcz","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemein-, Viszeral- und Transplantationschirurgie, LMU Klinikum, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen (LMU), M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorian","family":"Andrade","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemein-, Viszeral- und Transplantationschirurgie, LMU Klinikum, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen (LMU), M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Heiliger","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemein-, Viszeral- und Transplantationschirurgie, LMU Klinikum, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen (LMU), M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Ehrl","sequence":"additional","affiliation":[{"name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen (LMU), M\u00fcnchen, Germany"},{"name":"Klinik f\u00fcr Plastische, Rekonstruktive und Handchirurgie, Klinikum N\u00fcrnberg, N\u00fcrnberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2023.08.009"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12204"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/10732748231154711"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells9040992"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.30344"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3233\/CH-231814"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3233\/CH-231987"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2020.07.041"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.790661"},{"key":"e_1_3_2_12_2","first-page":"6449997","article-title":"Hypoxia-Related signature is a prognostic biomarker of pancreatic cancer","volume":"2022","author":"Zhang JJ","year":"2022","unstructured":"Zhang JJ, Shao C, Yin YX, et al. 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