{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T06:44:56Z","timestamp":1782629096560,"version":"3.54.5"},"reference-count":23,"publisher":"SAGE Publications","issue":"3-4","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clinical Hemorheology and Microcirculation"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Aortic stenosis is a common valvular disease in the elderly. This study aimed to investigate changes in whole blood viscosity (WBV), which reflects hemodynamic load and blood flow and is associated with cardiovascular diseases, after percutaneous and surgical interventions for aortic stenosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      From 2019 to 2022, 200 patients undergoing Transcatheter Aortic Valve Implantation (TAVI) (n\u2009=\u2009100) or bioprosthetic Aortic Valve Replacement (bAVR) (n\u2009=\u2009100) were analyzed. WBV at low shear rate (LSR, 0.5\u2005s\n                      <jats:sup>\u22121<\/jats:sup>\n                      ) and high shear rate (HSR, 208\u2005s\n                      <jats:sup>\u22121<\/jats:sup>\n                      ) was calculated from the hematocrit and total protein using the De Simone formula. Pre- and 3-month values were compared using paired and independent t-tests, and correlations and multivariable regression were performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The aortic valve area was negatively correlated with HSR (r\u2009=\u2009\u20130.340,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and LSR (r\u2009=\u2009\u20130.358,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.01). At 3 months, HSR decreased by 0.95\u2009\u00b1\u20090.31 cP and LSR by 18.92\u2009\u00b1\u20096.32 cP (both\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Reductions were significant in both groups without between-group differences and were mainly related to decreases in non-albumin protein fractions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both TAVI and bAVR markedly reduced WBV, independent of the intervention type. WBV may be a useful biomarker for monitoring hemorheological and protein-based changes following valve intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13860291261442998","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T12:38:23Z","timestamp":1779712703000},"page":"77-86","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Changes in whole blood viscosity in patients undergoing percutaneous or surgical intervention for aortic stenosis"],"prefix":"10.1177","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1263-5989","authenticated-orcid":false,"given":"Zeynep Esra","family":"G\u00fcner","sequence":"first","affiliation":[{"name":"Department of Cardiology, Uzunkopru State Hospital, Edirne, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4039-1259","authenticated-orcid":false,"given":"Ahmet","family":"Karaduman","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kosuyolu Research and Education Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1866-349X","authenticated-orcid":false,"given":"\u0130smail","family":"Balaban","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kosuyolu Research and Education Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1424-2209","authenticated-orcid":false,"given":"Bark\u0131n","family":"K\u00fclt\u00fcrsay","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tunceli State Hospital, Tunceli, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2545-6445","authenticated-orcid":false,"given":"Ravza Bet\u00fcl","family":"Akba\u015f","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Bitlis Tatvan State Hospital, Bitlis, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7552-7654","authenticated-orcid":false,"given":"U\u011fur","family":"\u00d6zkan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Trakya University School of Medicine, Edirne, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regayip","family":"Zehir","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kosuyolu Research and Education Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(03)00201-X"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","unstructured":"Jander N Minners J. Aortic stenosis: disease severity progression and timing of intervention. In: Otto CM (ed.) The practice of clinical echocardiography. 5th ed. Philadelphia: Elsevier 2017 pp.261\u2013286. Fig. 15-1.","DOI":"10.1016\/B978-0-323-40125-8.00015-9"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-020-01681-2"},{"key":"e_1_3_2_5_2","first-page":"6","article-title":"Evaluation of whole blood viscosity in patients with aortic sclerosis","volume":"12","author":"Duyuler PT","year":"2017","unstructured":"Duyuler PT, Duyuler S, \u0130leri M, et al. Evaluation of whole blood viscosity in patients with aortic sclerosis. 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