{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T20:46:14Z","timestamp":1785703574400,"version":"3.56.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"1-2","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clinical Hemorheology and Microcirculation"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Stroke is the leading cause of morbidity and mortality, and its management differs among ischemic stroke, hemorrhagic stroke, and stroke mimics. Non-contrast CT has limited sensitivity for early ischemia. This study compared blood and plasma viscosity across different stroke types and identified cutoff values for predicting stroke type.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      A cross-sectional study at the Emergency Department of Dr. Cipto Mangunkusumo National Referral Hospital (March\u2013June 2025). Blood and plasma viscosity were measured using the Neo Digital Microcapillary device then compared using appropriate statistic tests. A\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      -value &lt; 0.05 was considered statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy of 97 suspect stroke patients were included (36 ischemic, 16 hemorrhagic, 18 mimics). There were significant differences of blood viscocity between ischemic and hemorrhagic stroke compared with stroke mimic (median 5.65\u2005cP ischemic; 5.29\u2005cP hemorrhagic; 4.84\u2005cP mimic;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), whereas no significant difference was observed in plasma viscosity across the groups (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.411). A blood viscosity cutoff of 5.17\u2005cP yielded an AUC of 0.84 (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), 71.2% sensitivity, 94.4% specificity, 97.37% PPV, and 53.13% NPV for stroke prediction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Blood viscosity shows potential as an adjunctive diagnostic tool for distinguishing stroke from stroke mimics with high specificity, aiding in predicting types of stroke.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13860291261456431","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T10:50:58Z","timestamp":1781261458000},"page":"47-56","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Blood viscosity values for predicting pathological stroke types (ischemic stroke, hemorrhagic stroke, and stroke mimic) at DR. Cipto Mangunkusumo National Referral Hospital"],"prefix":"10.1177","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4838-3292","authenticated-orcid":false,"given":"Marco","family":"Lius","sequence":"first","affiliation":[{"name":"Clinical Pathology Department, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Public Hospital, Central Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sri Suryo","family":"Adiyanti","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Public Hospital, Central Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Al","family":"Rasyid","sequence":"additional","affiliation":[{"name":"Neurology Department, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Public Hospital, Central Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1964-0561","authenticated-orcid":false,"family":"Yusra","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Public Hospital, Central Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0195-6269","authenticated-orcid":false,"given":"Astuti","family":"Giantini","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Public Hospital, Central Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ro Shinta Christina","family":"Solin","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Public Hospital, Central Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,12]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.2991\/978-94-6463-048-0_50"},{"key":"e_1_3_3_3_2","first-page":"1424","article-title":"Imaging of hemorrhagic stroke","volume":"22","author":"Hakimi R","year":"2016","unstructured":"Hakimi R, Garg A. Imaging of hemorrhagic stroke. Am Acad Neurol 2016; 22: 1424\u20131450. Available from https:\/\/pubmed.ncbi.nlm.nih.gov\/27740983\/","journal-title":"Am Acad Neurol"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2021.1890205"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14069"},{"key":"e_1_3_3_6_2","unstructured":"Menteri kesehatan republik Indonesia. Pedoman Nasional Pelayanan Kedokteran Tatalaksana Stroke. 2019."},{"key":"e_1_3_3_7_2","article-title":"CT hypoperfusion-hypodensity mismatch to identify patients with acute ischemic stroke within 4.5 hours of symptom onset","volume":"97","author":"Sprons P","year":"2021","unstructured":"Sprons P, Kemmling A, Minnerup H, et al. CT hypoperfusion-hypodensity mismatch to identify patients with acute ischemic stroke within 4.5 hours of symptom onset. Neurology 2021; 97: e2088\u2013e2095.","journal-title":"Neurology"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hest.2022.07.003"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1320773"},{"key":"e_1_3_3_10_2","volume-title":"Human physiology: from cells to systems","author":"Sherwood L","year":"2019","unstructured":"Sherwood L, Ward C. Human physiology: from cells to systems. 4th ed. Toronto: Nelson Education Ltd., 2019.","edition":"4"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.53.suppl_1.49"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1602663"},{"key":"e_1_3_3_13_2","volume-title":"Efektivitas mikrokapiler digital sebagai alat ukur nilai viskositas darah untuk prediksi prognosis stroke iskemik akut","author":"Rasyid A","year":"2014","unstructured":"Rasyid A. Efektivitas mikrokapiler digital sebagai alat ukur nilai viskositas darah untuk prediksi prognosis stroke iskemik akut. Jakarta: Universitas Indonesia, 2014."},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(99)00114-8"},{"key":"e_1_3_3_15_2","volume-title":"StatPearls","author":"Unnithan A","year":"2023","unstructured":"Unnithan A, Das JM, Mehta P. Hemorrhagic stroke In: StatPearls [Internet]. Treasure Island: StatPearls Publishing, 2023 [cited 2024 Nov 4]; Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK559173\/?report=printable"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2024.122943"},{"key":"e_1_3_3_17_2","unstructured":"Gulhar R Ashraf MA Jialal I. Physiology Acute Phase Reactants. 2025."},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24086910"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101931"}],"container-title":["Clinical Hemorheology and Microcirculation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13860291261456431","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13860291261456431","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13860291261456431","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T19:47:45Z","timestamp":1785700065000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13860291261456431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":18,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1177\/13860291261456431"],"URL":"https:\/\/doi.org\/10.1177\/13860291261456431","relation":{},"ISSN":["1386-0291","1875-8622"],"issn-type":[{"value":"1386-0291","type":"print"},{"value":"1875-8622","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]}}}