{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T22:26:40Z","timestamp":1793572000116,"version":"4.5.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"1-2","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Scientific and Technological Research Council of T\u00fcrkiye","award":["108S289"],"award-info":[{"award-number":["108S289"]}],"id":[{"id":"https:\/\/ror.org\/04w9kkr77","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Recep Tayyip Erdo\u011fan University Research Foundation","award":["2. 102.02.2"],"award-info":[{"award-number":["2. 102.02.2"]}],"id":[{"id":"https:\/\/ror.org\/0468j1635","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clinical Hemorheology and Microcirculation"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atherosclerosis is a lipid-driven inflammatory disease in which plasma lipoproteins and cellular cholesterol pools contribute to coronary artery disease (CAD). Lipoprotein subfractions and erythrocyte membrane cholesterol (EMC) have each been linked to CAD, but their combined behavior across angiographic stages remains insufficiently characterized. EMC may also be relevant to blood flow properties and microcirculatory function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We studied 122 patients undergoing coronary angiography and 64 controls. CAD severity was classified by the number of diseased vessels. Plasma lipid profile, LDL and HDL subfractions, atherogenic indices, EMC, and C-reactive protein were analyzed using multivariable regression, ANCOVA, ROC analysis, and an exploratory multi-marker approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Conventional lipid parameters showed limited group differences, whereas sdLDL, HDL subfractions, EMC, CRP, and selected lipid ratios differed across CAD severity groups. EMC increased across CAD categories and remained associated with CAD after adjustment for conventional lipid variables. Among lipid-related variables, EMC showed the most consistent association with angiographically defined CAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>EMC may provide complementary hemorheology- and microcirculation-relevant information in angiographically defined CAD. Lipoprotein subfractions and composite lipid indices may offer adjunctive characterization of CAD-related lipid remodeling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13860291261490206","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:44:09Z","timestamp":1791996249000},"page":"21-31","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Lipoprotein subfractions, erythrocyte membrane cholesterol in coronary artery disease: A cross-sectional clinical study"],"prefix":"10.1177","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3860-3085","authenticated-orcid":false,"given":"H\u00fcseyin Avni","family":"Uydu","sequence":"first","affiliation":[{"name":"Samsun University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Bostan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Private Pendik Bolge Hospital, Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901143400207"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc0902.104353"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00238-0"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","unstructured":"Hansson GK. Inflammation atherosclerosis and coronary artery disease. N Engl J Med 2005; 352: 1685\u20131695.","DOI":"10.1056\/NEJMra043430"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.302721"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0106-z"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R800087-JLR200"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10146"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.7555\/JBR.31.20160103"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx144"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000183727.90611.4f"},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","unstructured":"El Harchaoui K Arsenault BJ Franssen R et al. High-density lipoprotein particle size and concentration and coronary risk. Ann Intern Med 2009; 150: 84\u201393.","DOI":"10.7326\/0003-4819-150-2-200901200-00006"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2014.11.003"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2023.06.107"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2023.101215"},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","unstructured":"Kolodgie FD Gold HK Burke AP et al. Intraplaque hemorrhage and progression of coronary atheroma. N Engl J Med 2003; 349: 2316\u20132325.","DOI":"10.1056\/NEJMoa035655"},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","unstructured":"Virmani R Kolodgie FD Burke AP et al. Lessons from sudden coronary death: A comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol 2000; 20: 1262\u20131275.","DOI":"10.1161\/01.ATV.20.5.1262"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0b013e328313819b"},{"key":"e_1_3_2_20_2","first-page":"390","article-title":"Total cholesterol content of erythrocyte membranes is associated with the severity of coronary artery disease and the therapeutic effect of rosuvastatin, Ups","volume":"117","author":"Zhong Y","year":"2012","unstructured":"Zhong Y, Tang H, Zeng Q, et al. Total cholesterol content of erythrocyte membranes is associated with the severity of coronary artery disease and the therapeutic effect of rosuvastatin, Ups. J Med Sci 2012; 117: 390\u2013398.","journal-title":"J Med Sci"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/821686"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.037166"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30010036"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-013-9611-2"},{"key":"e_1_3_2_25_2","doi-asserted-by":"crossref","unstructured":"Scanlon PJ Faxon DP Audet A-M et al. ACC\/AHA guidelines for coronary angiography: Executive summary and recommendations a report of the american college of cardiology\/American Heart Association task force on practice guidelines (Committee on Coronary Angiography) developed in collaboration with the society for cardiac angiography and interventions committee members. 1999. www.acc.org.","DOI":"10.1161\/01.CIR.99.17.2345"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.03.003"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.03.067"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(03)00111-5"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10061302"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(63)90042-0"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)39314-7"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.2307\/2531595"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2019.3780"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1080\/AC.70.3.3080638"},{"key":"e_1_3_2_35_2","first-page":"16","article-title":"Small LDL subfractions are associated with coronary atherosclerosis despite no differences in conventional lipids, physiol","volume":"55","author":"S\u00e6ther JC","year":"2023","unstructured":"S\u00e6ther JC, Klevjer M, Giske\u00f8deg\u00e5rd GF, et al. Small LDL subfractions are associated with coronary atherosclerosis despite no differences in conventional lipids, physiol. Genomics 2023; 55: 16\u201326.","journal-title":"Genomics"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)30178-X"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0b013e32833b7756"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.72.1059"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.3390\/membranes12111134."}],"container-title":["Clinical Hemorheology and Microcirculation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13860291261490206","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13860291261490206","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13860291261490206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T21:40:51Z","timestamp":1793569251000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13860291261490206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,14]]},"references-count":38,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["10.1177\/13860291261490206"],"URL":"https:\/\/doi.org\/10.1177\/13860291261490206","relation":{},"ISSN":["1386-0291","1875-8622"],"issn-type":[{"value":"1386-0291","type":"print"},{"value":"1875-8622","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,14]]}}}